ArticleDiagnostics (Basel, Switzerland)2017
A Pilot Study into the Association between Oral Health Status and Human Papillomavirus-16 Infection.
Article in Diagnostics (Basel, Switzerland), 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers, 2 of them syntheses that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
32 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Oro-facial mucocutaneous manifestations of Coronavirus Disease-2019 (COVID-19): A systematic review.PloS one · 2022Pooled it
- Sensitivity and specificity of oral HPV detection for HPV-positive head and neck cancer.Oral oncology · 2018Pooled it
- Role of viruses in periodontitis: An extensive review of herpesviruses, human immunodeficiency virus, coronavirus-19, papillomavirus and hepatitis viruses.World journal of virology · 2024Review
- Oral and periodontal manifestation related during human papilloma virus infections: Update on early prognostic factors.Heliyon · 2024Review
- Human papillomavirus (HPV) DNA methylation changes in HPV-associated head and neck cancer.Carcinogenesis · 2024Article
- Profiling salivary miRNA expression levels in Fanconi anemia patients - a pilot study.Odontology · 2024Article
- Article
- Circulating tumour DNA alterations: emerging biomarker in head and neck squamous cell carcinoma.Journal of biomedical science · 2023Review
- A salivary biomarker panel to detect liver cirrhosis.iScience · 2023Article
- Salivary micro RNAs as biomarkers for oropharyngeal cancer.Cancer medicine · 2023Article
- Saliva-based microfluidic point-of-care diagnostic.Theranostics · 2023Review
- Effect of National Oral Health Screening Program on the Risk of Head and Neck Cancer: A Korean National Population-Based Study.Cancer research and treatment · 2022Article
- An Exploratory Study Demonstrating That Salivary Cytokine Profiles Are Altered in Children With Small Area Thermal Injury.Journal of burn care & research : official publication of the American Burn Association · 2022Article
- Investigation of the Relationship between Oral Human Papillomavirus Infection and Oral Health.Journal of dentistry (Shiraz, Iran) · 2022Article
- Article
- Salivary High-Risk Human Papillomavirus (HPV) DNA as a Biomarker for HPV-Driven Head and Neck Cancers.The Journal of molecular diagnostics : JMD · 2021Article
- Proteomic Alterations in Salivary Exosomes Derived from Human Papillomavirus-Driven Oropharyngeal Cancer.Molecular diagnosis & therapy · 2021Article
- Relationship between the prevalence of oral human papillomavirus DNA and periodontal disease (Review).Biomedical reports · 2021Review
- Expression of p16The Indian journal of medical research · 2021Article
- Association of oral HPV16 infection with periodontal inflammation and the oral microbiome in older women.Experimental and therapeutic medicine · 2021Article
Corrections and comments
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Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundOver the next 20 years, oropharyngeal cancers (OPC) will represent the majority of head and neck cancers (HNCs) in the United States. It is estimated that human papillomavirus (HPV) may account for as much as 70% to 80% of OPCs in North America and in certain parts of Europe. It is hence crucial to understand the disease risk factors and natural history of oral HPV infections. We hypothesized that poor oral health (by measures such as poor oral hygiene and periodontal disease) leads to a higher degree of oral HPV-16 infections within a patient cohort from a dental school clinic. This study aims to test this hypothesis and gauge possible disease associations before larger scale studies. SUBJECTS AND
methods223 participants were recruited in this study from the University of Queensland Dental School clinic. Clinical oral health parameters (such as oral hygiene measures and periodontal disease measurements) have been examined and determined by dental professionals. We have collected oral rinse samples from these volunteers.
results10 (4.5%) out of 223 participants were found to have HPV-16 DNA in their oral rinse samples using NB2 endpoint PCR and Sanger sequencing. Within the HPV-16 DNA positive subjects, 7 (70%) and 3 (30%) were associated with poor oral hygiene and periodontal disease, respectively.
conclusionOur results show a trend towards a positive correlation between oral HPV-16 infection and poor clinical oral health status.
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