Evidence map›Paper›PMID 28257001›Full record

ArticleeLife2017

Origin and evolution of transporter substrate specificity within the NPF family.

Morten Egevang Jørgensen, Deyang Xu, Christoph Crocoll, Heidi Asschenfeldt Ernst, David Ramírez, Mohammed Saddik Motawia, Carl Erik Olsen, Osman Mirza, Hussam Hassan Nour-Eldin, Barbara Ann Halkier

Erratum issuedAbstract read
In one paragraph

Article in eLife, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 57 papers.

0numbers the graph read from it
0cells of the map it votes in
57citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

57 citing papers in PubMed.

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  15. Deorphanizing solute carriers inFrontiers in microbiology · 2024
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

10 authors.

Morten Egevang JørgensenDynaMo Center, Department of Plant and Environmental Sciences, Faculty of Science, University of Copenhagen, Frederiksberg, Denmark.ORCID http://orcid.org/0000-0001-6503-0495
Deyang XuDynaMo Center, Department of Plant and Environmental Sciences, Faculty of Science, University of Copenhagen, Frederiksberg, Denmark.ORCID http://orcid.org/0000-0003-1015-6458
Christoph CrocollDynaMo Center, Department of Plant and Environmental Sciences, Faculty of Science, University of Copenhagen, Frederiksberg, Denmark.
Heidi Asschenfeldt ErnstDepartment of Drug Design and Pharmacology, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
David RamírezCentro de Bioinformática y Simulación Molecular (CBSM), Universidad de Talca, Talca, Chile.
Mohammed Saddik MotawiaCenter for Plant Plasticity, Department of Plant and Environmental Sciences, Faculty of Science, University of Copenhagen, Frederiksberg, Denmark.
Carl Erik OlsenDepartment of Plant and Environmental Sciences, Faculty of Science, University of Copenhagen, Frederiksberg, Denmark.
Osman MirzaDepartment of Drug Design and Pharmacology, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
Hussam Hassan Nour-EldinDynaMo Center, Department of Plant and Environmental Sciences, Faculty of Science, University of Copenhagen, Frederiksberg, Denmark.ORCID http://orcid.org/0000-0001-6660-0509
Barbara Ann HalkierDynaMo Center, Department of Plant and Environmental Sciences, Faculty of Science, University of Copenhagen, Frederiksberg, Denmark.ORCID http://orcid.org/0000-0002-3742-702X

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Despite vast diversity in metabolites and the matching substrate specificity of their transporters, little is known about how evolution of transporter substrate specificities is linked to emergence of substrates via evolution of biosynthetic pathways. Transporter specificity towards the recently evolved glucosinolates characteristic of

Indexed as

Evolution, MolecularGlucosinolatesMagnoliopsidaMembrane Transport ProteinsPhylogenySubstrate SpecificityGlucosinolatesMembrane Transport ProteinsA. thalianabiochemistrycyanogenic glucoside transportindole glucosinolate transportmetabolite transportersplant biologysubstrate specificity and electrogenicitytransporter evolutionxenopus

Identifiers

PMID28257001
PMCPMC5336358

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.