ArticleThe Journal of comparative neurology2017
Levodopa response differs in Parkinson's motor subtypes: A task-based effective connectivity study.
Article in The Journal of comparative neurology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers, 3 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
27 citing papers in PubMed, 3 syntheses or guidelines pooled it, 41 citations in OpenAlex.
- Brain Motor Network Changes in Parkinson's Disease: Evidence from Meta-Analytic Modeling.Movement disorders : official journal of the Movement Disorder Society · 2021Pooled it
- Quantitative Electroencephalography Characteristics for Parkinson's Disease: A Systematic Review.Journal of Parkinson's disease · 2020Pooled it
- Assessing White Matter Pathology in Early-Stage Parkinson Disease Using Diffusion MRI: A Systematic Review.Frontiers in neurology · 2020Pooled it
- A Self-Administered, Digitized Approach to Quantifying the Cardinal Motor Symptoms in Parkinson's Disease.Sensors (Basel, Switzerland) · 2026Article
- Relationship Between Head Trauma History and Motor Subtype in Early Parkinson's Disease.Medicina (Kaunas, Lithuania) · 2026Article
- Cerebral cortical activation and functional connectivity characteristics of children with unilateral cerebral palsy during a single-session virtual reality throwing motor task: a functional near-infrared spectroscopy study.Frontiers in rehabilitation sciences · 2026Article
- Dopaminergic Degeneration Differentially Modulates Primary Motor Cortex Activity and Motor Behavior in Hemiparkinsonian Rats.Brain sciences · 2025Article
- Case Study 8: A 70-Year-Old Man With Memory Loss, Wandering, and Inappropriate Behaviors.The Journal of neuropsychiatry and clinical neurosciences · 2025Article
- Resting-state functional magnetic resonance imaging study comparing tremor-dominant and postural instability/gait difficulty subtypes of Parkinson's disease.La Radiologia medica · 2023Article
- Real-World Driving Data Indexes Dopaminergic Treatment Effects in Parkinson's Disease.Movement disorders clinical practice · 2023Article
- Postural control of Parkinson's disease: A visualized analysis based on Citespace knowledge graph.Frontiers in aging neuroscience · 2023Review
- Chaudhuri's Dashboard of Vitals in Parkinson's syndrome: an unmet need underpinned by real life clinical tests.Frontiers in neurology · 2023Review
- Free water imaging unravels unique patterns of longitudinal structural brain changes in Parkinson's disease subtypes.Frontiers in neurology · 2023Article
- Distinct changes in global brain synchronization in different motor subtypes of Parkinson's disease.Frontiers in neuroscience · 2023Article
- Acupuncture Regulates Symptoms of Parkinson's DiseaseFrontiers in aging neuroscience · 2022Article
- The Effects of Non-Invasive Brain Stimulation on Quantitative EEG in Patients With Parkinson's Disease: A Systematic Scoping Review.Frontiers in neurology · 2022Article
- Does Subthalamic Deep Brain Stimulation Impact Asymmetry and Dyscoordination of Gait in Parkinson's Disease?Neurorehabilitation and neural repair · 2021Article
- Neuroimaging Detectable Differences between Parkinson's Disease Motor Subtypes: A Systematic Review.Movement disorders clinical practice · 2021Review
- Altered Spontaneous Neural Activity and Functional Connectivity in Parkinson's Disease With Subthalamic Microlesion.Frontiers in neuroscience · 2021Article
- Speech disorder and vocal tremor in postural instability/gait difficulty and tremor dominant subtypes of Parkinson's disease.Journal of neural transmission (Vienna, Austria : 1996) · 2020Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
Parkinson's disease (PD) is a circuit-level disorder with clinically-determined motor subtypes. Despite evidence suggesting each subtype may have different pathophysiology, few neuroimaging studies have examined levodopa-induced differences in neural activation between tremor dominant (TD) and postural instability/gait difficulty (PIGD) subtype patients during a motor task. The goal of this functional MRI (fMRI) study was to examine task-induced activation and connectivity in the cortico-striatal-thalamo-cortical motor circuit in healthy controls, TD patients, and PIGD patients before and after levodopa administration. Fourteen TD and 12 PIGD cognitively-intact patients and 21 age- and sex-matched healthy controls completed a right-hand, paced tapping fMRI paradigm. Collectively, PD patients off medication (OFF) showed hypoactivation of the motor cortex relative to healthy controls, even when controlling for performance. After levodopa intake, the PIGD patients had significantly increased activation in the left putamen compared with TD patients and healthy controls. Psychophysiological interaction analysis revealed that levodopa increased effective connectivity between the posterior putamen and other areas of the motor circuit during tapping in TD patients, but not in PIGD patients. This novel, levodopa-induced difference in the neural responses between PD motor subtypes may have significant implications for elucidating the mechanisms underlying the distinct phenotypic manifestations and enabling the classification of motor subtypes objectively using fMRI.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.