Evidence map›Paper›PMID 28256618›Full record

ArticleScientific reports2017

The Expanding Family of Natural Anion Channelrhodopsins Reveals Large Variations in Kinetics, Conductance, and Spectral Sensitivity.

Elena G Govorunova, Oleg A Sineshchekov, Elsa M Rodarte, Roger Janz, Olivier Morelle, Michael Melkonian, Gane K-S Wong, John L Spudich

Open access · goldAbstract read
In one paragraph

Article in Scientific reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 58 papers.

0numbers the graph read from it
0cells of the map it votes in
58citing papers in PubMed
6.1field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

58 citing papers in PubMed, 111 citations in OpenAlex.

  1. Article
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  8. Genetics-Based Targeting Strategies for Precise Neuromodulation.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025
    Review
  9. Article
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  17. Review
  18. Article
  19. Review
  20. Microbial Rhodopsins.Methods in molecular biology (Clifton, N.J.) · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 4 countries.

Elena G GovorunovaCenter for Membrane Biology, Department of Biochemistry &Molecular Biology, The University of Texas Health Science Center at Houston, McGovern Medical School, Houston, Texas, USA.
Oleg A SineshchekovCenter for Membrane Biology, Department of Biochemistry &Molecular Biology, The University of Texas Health Science Center at Houston, McGovern Medical School, Houston, Texas, USA.
Elsa M RodarteDepartment of Neurobiology &Anatomy, The University of Texas Health Science Center at Houston, McGovern Medical School, Houston, Texas, USA.
Roger JanzDepartment of Neurobiology &Anatomy, The University of Texas Health Science Center at Houston, McGovern Medical School, Houston, Texas, USA.
Olivier MorelleInstitute of Botany, Cologne Biocenter, University of Cologne, Cologne, Germany.
Michael MelkonianInstitute of Botany, Cologne Biocenter, University of Cologne, Cologne, Germany.
Gane K-S WongDepartments of Biological Sciences and of Medicine, University of Alberta, Edmonton, Alberta, Canada.
John L SpudichCenter for Membrane Biology, Department of Biochemistry &Molecular Biology, The University of Texas Health Science Center at Houston, McGovern Medical School, Houston, Texas, USA.
The University of Texas Health Science Center at Houston · USUniversity of Cologne · DEBGI Group (China) · CN

Funding

Structure/Function of Microbial Sensory RhodopsinsR01GM027750 · NIGMS · YESHIVA UNIVERSITY · PI SPUDICH, JOHN LEE · 1985 to 2020
$6.6M
Anion channelrhodopsin-based viral tools to manipulate brain networks in behaving animalsU01MH109146 · NIMH · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI DRAGOI, VALENTIN, JANZ, ROGER · 2015 to 2017
$3.0M
NIGMS NIH HHS R01 GM027750NIMH NIH HHS U01 MH109146
6 · The paper itself

Abstract

Natural anion channelrhodopsins (ACRs) discovered in the cryptophyte alga Guillardia theta generate large hyperpolarizing currents at membrane potentials above the Nernst equilibrium potential for Cl

Indexed as

Action PotentialsAmino AcidsAmino Acid SequenceAnimalsChannelrhodopsinsChloridesConserved SequenceCryptophytaElectric ConductivityGene ExpressionHEK293 CellsHippocampusHumansIon TransportLightMiceAmino AcidsChannelrhodopsinsChlorides

Identifiers

PMID28256618
PMCPMC5335703
OpenAlexW2593902424

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.