ArticleScientific reports2017
Cholesterol depletion impairs contractile machinery in neonatal rat cardiomyocytes.
Article in Scientific reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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Who cites it
26 citing papers in PubMed, 53 citations in OpenAlex.
- Cholesterol-depleting dextrin depolarizes sarcolemma: the contribution of sodium / calcium channels and membrane integrity.Pflugers Archiv : European journal of physiology · 2026Article
- Sepsis-induced hypocholesterolemia is linked to low cardiomyocyte membrane cholesterol and impaired catecholamine responsiveness.Critical care (London, England) · 2025Observational
- Contractile responses of engineered humanAPL bioengineering · 2024Article
- Inverse relationship between LDL-C/HDL-C ratio and atrial fibrillation in chronic kidney disease patients.Scientific reports · 2024Article
- p140Cap modulates the mevalonate pathway decreasing cell migration and enhancing drug sensitivity in breast cancer cells.Cell death & disease · 2023Article
- The Muscarinic Acetylcholine MCells · 2023Article
- Serum fibrinogen-to-albumin ratio predicts new-onset atrial fibrillation risk during hospitalization in patients with acute myocardial infarction after percutaneous coronary intervention: a retrospective study.BMC cardiovascular disorders · 2023Article
- Dietary Cholesterol Differentially Regulates the Muscle Lipidomics of Farmed Turbot and Tiger Puffer.Animals : an open access journal from MDPI · 2023Article
- Lipid Levels and New-Onset Atrial Fibrillation in Patients with Acute Myocardial Infarction.Journal of atherosclerosis and thrombosis · 2023Article
- Spatial organization of lysosomal exocytosis relies on membrane tension gradients.Proceedings of the National Academy of Sciences of the United States of America · 2023Article
- Low lipoprotein(a) concentration is associated with atrial fibrillation: a large retrospective cohort study.Lipids in health and disease · 2022Article
- Circulating plasma galectin-3 predicts new-onset atrial fibrillation in patients after acute myocardial infarction during hospitalization.BMC cardiovascular disorders · 2022Article
- Relationship between lipoproteins, thrombosis, and atrial fibrillation.Cardiovascular research · 2022Review
- Body Mass Index and New-Onset Atrial Fibrillation in Patients with Acute Myocardial Infarction.International journal of general medicine · 2022Article
- Association between triglyceride-glucose index and atrial fibrillation: A retrospective observational study.Frontiers in endocrinology · 2022Observational
- Article
- Cardiac Myoediting Attenuates Cardiac Abnormalities in Human and Mouse Models of Duchenne Muscular Dystrophy.Circulation research · 2021Article
- Dense optical flow software to quantify cellular contractility.Cell reports methods · 2021Article
- Protocol to measure the membrane tension and bending modulus of cells using optical tweezers and scanning electron microscopy.STAR protocols · 2021Article
- Membrane cholesterol regulates TRPV4 function, cytoskeletal expression, and the cellular response to tension.Journal of lipid research · 2021Article
Corrections and comments
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Authors and funding
5 authors at 3 institutions in 2 countries.
Funding
Abstract
Cholesterol regulates numerous cellular processes. Depleting its synthesis in skeletal myofibers induces vacuolization and contraction impairment. However, little is known about how cholesterol reduction affects cardiomyocyte behavior. Here, we deplete cholesterol by incubating neonatal cardiomyocytes with methyl-beta-cyclodextrin. Traction force microscopy shows that lowering cholesterol increases the rate of cell contraction and generates defects in cell relaxation. Cholesterol depletion also increases membrane tension, Ca
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Registered trials
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