ArticleScientific reports2017
The genome of Leishmania adleri from a mammalian host highlights chromosome fission in Sauroleishmania.
Article in Scientific reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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Who cites it
25 citing papers in PubMed, 44 citations in OpenAlex.
- Zoonotic leishmaniasis in China: Current status and challenges to elimination.PLoS neglected tropical diseases · 2026Review
- Partners in time: Cospeciation and host-switching shape the evolution of Leishmania parasites.PLoS neglected tropical diseases · 2025Article
- Unraveling the Genome Diversity ofLife (Basel, Switzerland) · 2025Review
- A novel strain of Leishmania braziliensis harbors not a toti- but a bunyavirus.PLoS neglected tropical diseases · 2024Article
- FVB/NJ strain as a mouse model for cutaneous leishmaniasis by Leishmania (L.) amazonensis.Memorias do Instituto Oswaldo Cruz · 2024Article
- Evolution of RNA viruses in trypanosomatids: new insights from the analysis of Sauroleishmania.Parasitology research · 2023Article
- Discovery of the vector of visceral leishmaniasis,Current research in parasitology & vector-borne diseases · 2023Article
- Leishmania tarentolae: A new frontier in the epidemiology and control of the leishmaniases.Transboundary and emerging diseases · 2022Review
- High genome plasticity and frequent genetic exchange in Leishmania tropica isolates from Afghanistan, Iran and Syria.PLoS neglected tropical diseases · 2021Article
- Development of VariousMicroorganisms · 2021Article
- Genomics of Trypanosomatidae: Where We Stand and What Needs to Be Done?Pathogens (Basel, Switzerland) · 2021Review
- Leishmania tarentolae and Leishmania infantum in humans, dogs and cats in the Pelagie archipelago, southern Italy.PLoS neglected tropical diseases · 2021Article
- Reptile vector-borne diseases of zoonotic concern.International journal for parasitology. Parasites and wildlife · 2021Review
- Genome Analysis ofGenes · 2021Article
- The Experimental Proteome ofGenes · 2020Article
- Application of next generation sequencing (NGS) for descriptive analysis of 30 genomes of Leishmania infantum isolates in Middle-North Brazil.Scientific reports · 2020Article
- Analysis of the IGS rRNA Region and Applicability forJournal of parasitology research · 2020Article
- Comparative genomics of Leishmania (Mundinia).BMC genomics · 2019Article
- Article
- Aneuploidy in yeast: Segregation error or adaptation mechanism?Yeast (Chichester, England) · 2019Article
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Authors and funding
6 authors at 4 institutions in 3 countries.
Funding
Abstract
Control of pathogens arising from humans, livestock and wild animals can be enhanced by genome-based investigation. Phylogenetically classifying and optimal construction of these genomes using short sequence reads are key to this process. We examined the mammal-infecting unicellular parasite Leishmania adleri belonging to the lizard-infecting Sauroleishmania subgenus. L. adleri has been associated with cutaneous disease in humans, but can be asymptomatic in wild animals. We sequenced, assembled and investigated the L. adleri genome isolated from an asymptomatic Ethiopian rodent (MARV/ET/75/HO174) and verified it as L. adleri by comparison with other Sauroleishmania species. Chromosome-level scaffolding was achieved by combining reference-guided with de novo assembly followed by extensive improvement steps to produce a final draft genome with contiguity comparable with other references. L. tarentolae and L. major genome annotation was transferred and these gene models were manually verified and improved. This first high-quality draft Leishmania adleri reference genome is also the first Sauroleishmania genome from a non-reptilian host. Comparison of the L. adleri HO174 genome with those of L. tarentolae Parrot-TarII and lizard-infecting L. adleri RLAT/KE/1957/SKINK-7 showed extensive gene amplifications, pervasive aneuploidy, and fission of chromosomes 30 and 36. There was little genetic differentiation between L. adleri extracted from mammals and reptiles, highlighting challenges for leishmaniasis surveillance.
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