ArticleScientific reports2017
Hydraulic forces contribute to left ventricular diastolic filling.
Article in Scientific reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed.
- Single-beat method echocardiographic comparison of ventricular-arterial coupling in adults with and without Down syndrome.American journal of physiology. Heart and circulatory physiology · 2026Article
- Bio-orthogonally double cross-linked alginate-gelatin hydrogels with tunable viscoelasticity for cardiac tissue engineering.Materials today. Bio · 2025Article
- Left Ventricular Diastolic Function in Children with Atrial Septal Defects Improves After Closure by Means of Increased Hydraulic Force.Pediatric cardiology · 2025Article
- Atrioventricular Area Difference Aids Diastolic Filling in Patients with Repaired Tetralogy of Fallot.Pediatric cardiology · 2025Article
- Exercise cardiovascular magnetic resonance shows improved diastolic filling by atrioventricular area difference in athletes and controls.Journal of applied physiology (Bethesda, Md. : 1985) · 2024Article
- Estimate of the hydraulic force in the aging heart: a cardiovascular magnetic resonance imaging study.BMC medical imaging · 2024Article
- Diastology of the Transplanted Heart: Is the Geometrical Relationship of the Left Atrium the Missing Link?Journal of the American Heart Association · 2024Article
- Diastolic Filling in Patients After Heart Transplantation Is Impaired Due to an Altered Geometrical Relationship Between the Left Atrium and Ventricle.Journal of the American Heart Association · 2024Article
- Decreased diastolic hydraulic forces incrementally associate with survival beyond conventional measures of diastolic dysfunction.Scientific reports · 2023Article
- Heart Failure with Preserved Left Ventricular Ejection Fraction: A Complex Conundrum Simply Not Limited to Diastolic Dysfunction.Cardiovascular therapeutics · 2023Review
- Article
- Mechanics of right ventricular dysfunction in pulmonary arterial hypertension and heart failure with preserved ejection fraction.Cardiovascular diagnosis and therapy · 2020Review
- Mitral Annular Dynamics and Left Ventricular Diastole.Cardiology research · 2017Article
- Hydraulic forces assist left ventricular filling in aortic stenosis at baseline and after valve replacement.Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic ResonanceObservational
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Myocardial active relaxation and restoring forces are known determinants of left ventricular (LV) diastolic function. We hypothesize the existence of an additional mechanism involved in LV filling, namely, a hydraulic force contributing to the longitudinal motion of the atrioventricular (AV) plane. A prerequisite for the presence of a net hydraulic force during diastole is that the atrial short-axis area (ASA) is smaller than the ventricular short-axis area (VSA). We aimed (a) to illustrate this mechanism in an analogous physical model, (b) to measure the ASA and VSA throughout the cardiac cycle in healthy volunteers using cardiovascular magnetic resonance imaging, and (c) to calculate the magnitude of the hydraulic force. The physical model illustrated that the anatomical difference between ASA and VSA provides the basis for generating a hydraulic force during diastole. In volunteers, VSA was greater than ASA during 75-100% of diastole. The hydraulic force was estimated to be 10-60% of the peak driving force of LV filling (1-3 N vs 5-10 N). Hydraulic forces are a consequence of left heart anatomy and aid LV diastolic filling. These findings suggest that the relationship between ASA and VSA, and the associated hydraulic force, should be considered when characterizing diastolic function and dysfunction.
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