Evidence map›Paper›PMID 28256601›Full record

ArticleScientific reports2017

Complete mitochondrial sequences from Mesolithic Sardinia.

Alessandra Modi, Francesca Tassi, Roberta Rosa Susca, Stefania Vai, Ermanno Rizzi, Gianluca De Bellis, Carlo Lugliè, Gloria Gonzalez Fortes, Martina Lari, Guido Barbujani and 2 more

Abstract read
In one paragraph

Article in Scientific reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed.

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  8. A genetic perspective on Longobard-Era migrations.European journal of human genetics : EJHG · 2019
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Alessandra ModiDipartimento di Biologia, Università di Firenze, 50122 Florence, Italy.
Francesca TassiDipartimento di Scienze della Vita e Biotecnologie, Università di Ferrara, 44121 Ferrara, Italy.
Roberta Rosa SuscaDipartimento di Scienze della Vita e Biotecnologie, Università di Ferrara, 44121 Ferrara, Italy.
Stefania VaiDipartimento di Biologia, Università di Firenze, 50122 Florence, Italy.
Ermanno RizziFondazione Telethon, 20121 Milano, Italy.
Gianluca De BellisIstituto di Tecnologie Biomediche, CNR, 20090 Segrate, Milano, Italy.
Carlo LuglièLASP, Dipartimento di Storia, Beni Culturali e Territorio, Università di Cagliari, 09124 Cagliari, Italy.
Gloria Gonzalez FortesDipartimento di Scienze della Vita e Biotecnologie, Università di Ferrara, 44121 Ferrara, Italy.
Martina LariDipartimento di Biologia, Università di Firenze, 50122 Florence, Italy.
Guido BarbujaniDipartimento di Scienze della Vita e Biotecnologie, Università di Ferrara, 44121 Ferrara, Italy.
David CaramelliDipartimento di Biologia, Università di Firenze, 50122 Florence, Italy.
Silvia GhirottoDipartimento di Scienze della Vita e Biotecnologie, Università di Ferrara, 44121 Ferrara, Italy.

Funding

European Research Council 295733
6 · The paper itself

Abstract

Little is known about the genetic prehistory of Sardinia because of the scarcity of pre-Neolithic human remains. From a genetic perspective, modern Sardinians are known as genetic outliers in Europe, showing unusually high levels of internal diversity and a close relationship to early European Neolithic farmers. However, how far this peculiar genetic structure extends and how it originated was to date impossible to test. Here we present the first and oldest complete mitochondrial sequences from Sardinia, dated back to 10,000 yBP. These two individuals, while confirming a Mesolithic occupation of the island, belong to rare mtDNA lineages, which have never been found before in Mesolithic samples and that are currently present at low frequencies not only in Sardinia, but in the whole Europe. Preliminary Approximate Bayesian Computations, restricted by biased reference samples for Mesolithic Sardinia (the two typed samples) and Neolithic Europe (limited to central and north European sequences), suggest that the first inhabitants of the island have had a small or negligible contribution to the present-day Sardinian population, which mainly derives its genetic diversity from continental migration into the island by Neolithic times.

Indexed as

Genetic VariationGenome, MitochondrialBayes TheoremEvolution, MolecularGenetics, PopulationHigh-Throughput Nucleotide SequencingHumansItalyPhylogenySequence Analysis, DNA

Identifiers

PMID28256601
PMCPMC5335606

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.