ArticleScientific reports2017
Chitosan-coated mesoporous MIL-100(Fe) nanoparticles as improved bio-compatible oral nanocarriers.
Article in Scientific reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
33 citing papers in PubMed.
- Development and Characterization of Celecoxib-Loaded Soluplus/Zein Composite Nanoparticles Coated with Chitosan for Pulmonary Drug Delivery.ACS omega · 2026Article
- Metal-organic frameworks for biomedical applications: bridging materials science and regenerative medicine.RSC advances · 2025Review
- Design, fabrication and characterization of a magnetite-chitosan coated iron-based metal-organic framework (FeRSC advances · 2025Article
- Iron-MOFs for Biomedical Applications.Advanced healthcare materials · 2025Review
- Effect of Chitosan Coating on Drug Carrier Capacity of Metal-organic Framework MIL-100(Fe) Contained Cyclophosphamide.Current medicinal chemistry · 2025Article
- Metal-organic frameworks in oral drug delivery.Asian journal of pharmaceutical sciences · 2024Article
- Baicalin nanodelivery system based on functionalized metal-organic framework for targeted therapy of osteoarthritis by modulating macrophage polarization.Journal of nanobiotechnology · 2024Article
- Metal-Organic Framework-Mediated Delivery of Nucleic Acid across Intact Plant Cells.ACS applied materials & interfaces · 2024Review
- Current status of Fe-based MOFs in biomedical applications.RSC medicinal chemistry · 2023Review
- Interfacing metal organic frameworks with polymers or carbon-based materials: from simple to hierarchical porous and nanostructured composites.Chemical science · 2023Review
- Chitosan-Coated MIL-100(Fe) as an Anticancer Drug Carrier: Theoretical and Experimental Investigation.ACS medicinal chemistry letters · 2023Article
- Alignment of Breathing Metal-Organic Framework Particles for Enhanced Water-Driven Actuation.Chemistry of materials : a publication of the American Chemical Society · 2023Article
- Mitigating Metal-Organic Framework (MOF) Toxicity for Biomedical Applications.Chemical engineering journal (Lausanne, Switzerland : 1996) · 2023Article
- Macrophage Cell Membrane Coating on Piperine-Loaded MIL-100(Fe) Nanoparticles for Breast Cancer Treatment.Journal of functional biomaterials · 2023Article
- In Situ Spectroscopic Studies of NHACS omega · 2023Article
- Recent Advances in Research on the Effect of Physicochemical Properties on the Cytotoxicity of Metal-Organic Frameworks.Small science · 2022Article
- Chitosan Containing Nano Zn-Organic Framework: Synthesis, Characterization and Biological Activity.Polymers · 2022Article
- Cracking the immune fingerprint of metal-organic frameworks.Chemical science · 2022Article
- Anti-inflammatory and antioxidant effects of nanoformulations composed of metal-organic frameworks delivering rutin and/or piperine natural agents.Drug delivery · 2021Article
- Metal-organic frameworks for advanced drug delivery.Acta pharmaceutica Sinica. B · 2021Review
Corrections and comments
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Authors and funding
13 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Nanometric biocompatible Metal-Organic Frameworks (nanoMOFs) are promising candidates for drug delivery. Up to now, most studies have targeted the intravenous route, related to pain and severe complications; whereas nanoMOFs for oral administration, a commonly used non-invasive and simpler route, remains however unexplored. We propose here the biofriendly preparation of a suitable oral nanocarrier based on the benchmarked biocompatible mesoporous iron(III) trimesate nanoparticles coated with the bioadhesive polysaccharide chitosan (CS). This method does not hamper the textural/structural properties and the sorption/release abilities of the nanoMOFs upon surface engineering. The interaction between the CS and the nanoparticles has been characterized through a combination of high resolution soft X-ray absorption and computing simulation, while the positive impact of the coating on the colloidal and chemical stability under oral simulated conditions is here demonstrated. Finally, the intestinal barrier bypass capability and biocompatibility of CS-coated nanoMOF have been assessed in vitro, leading to an increased intestinal permeability with respect to the non-coated material, maintaining an optimal biocompatibility. In conclusion, the preservation of the interesting physicochemical features of the CS-coated nanoMOF and their adapted colloidal stability and progressive biodegradation, together with their improved intestinal barrier bypass, make these nanoparticles a promising oral nanocarrier.
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