ArticleScientific reports2017
Capillary flow-driven microfluidic device with wettability gradient and sedimentation effects for blood plasma separation.
Article in Scientific reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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20 citing papers in PubMed, 92 citations in OpenAlex.
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- Microfluidics and nanofluidics in India - some recent advancements and futuristic perspective.Biomicrofluidics · 2025Article
- Microfluidic Chip for Quantitatively Assessing Hemorheological Parameters.Micromachines · 2025Article
- Capillary Force-Driven Quantitative Plasma Separation Method for Application of Whole Blood Detection Microfluidic Chip.Micromachines · 2024Article
- Dean vortex-enhanced blood plasma separation in self-driven spiral microchannel flow with cross-flow microfilters.Biomicrofluidics · 2024Article
- Modified polysulfone membrane facilitates rapid separation of plasma from whole blood for an effective anti-SARS-CoV-2-IgM diagnosis.Scientific reports · 2023Article
- Design and Fabrication of a High Performance Microfluidic Chip for Blood Plasma Separation: Modelling and Prediction of System Behaviour via CFD Method.International journal of analytical chemistry · 2023Article
- Understanding microbeads stacking in deformable Nano-Sieve for Efficient plasma separation and blood cell retrieval.Journal of colloid and interface science · 2022Article
- Visible-light and near-infrared fluorescence and surface-enhanced Raman scattering point-of-care sensing and bio-imaging: a review.Chemical Society reviews · 2022Review
- LSPR based on-chip detection of dengue NS1 antigen in whole blood.RSC advances · 2021Article
- High-Performance Passive Plasma Separation on OSTE Pillar Forest.Biosensors · 2021Article
- Blood Plasma Self-Separation Technologies during the Self-Driven Flow in Microfluidic Platforms.Bioengineering (Basel, Switzerland) · 2021Review
- Drop-of-blood acoustic tweezing technique for integrative turbidimetric and elastometric measurement of blood coagulation.Analytical and bioanalytical chemistry · 2021Article
- Molecular diffusion analysis of dynamic blood flow and plasma separation driven by self-powered microfluidic devices.Biomicrofluidics · 2021Article
- Nano-Interstice Driven Powerless Blood Plasma Extraction in a Membrane Filter Integrated Microfluidic Device.Sensors (Basel, Switzerland) · 2021Article
- Closable Valves and Channels for Polymeric Microfluidic Devices.Micromachines · 2020Article
- Representative subsampling of sedimenting blood.Proceedings. Mathematical, physical, and engineering sciences · 2019Article
- Article
- Micropatterned macroporous structures in microfluidic devices for viral separation from whole blood.The Analyst · 2017Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We report a capillary flow-driven microfluidic device for blood-plasma separation that comprises a cylindrical well between a pair of bottom and top channels. Exposure of the well to oxygen-plasma creates wettability gradient on its inner surface with its ends hydrophilic and middle portion hydrophobic. Due to capillary action, sample blood self-infuses into bottom channel and rises up the well. Separation of plasma occurs at the hydrophobic patch due to formation of a 'self-built-in filter' and sedimentation. Capillary velocity is predicted using a model and validated using experimental data. Sedimentation of RBCs is explained using modified Steinour's model and correlation between settling velocity and liquid concentration is found. Variation of contact angle on inner surface of the well is characterized and effects of well diameter and height and dilution ratio on plasma separation rate are investigated. With a well of 1.0 mm diameter and 4.0 mm height, 2.0 μl of plasma was obtained (from <10 μl whole blood) in 15 min with a purification efficiency of 99.9%. Detection of glucose was demonstrated with the plasma obtained. Wetting property of channels was maintained by storing in DI water under vacuum and performance of the device was found to be unaffected over three weeks.
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