ArticleScientific reports2017
Family-based case-control study of homotopic connectivity in first-episode, drug-naive schizophrenia at rest.
Article in Scientific reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 2 of them syntheses that pooled it.
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Who cites it
13 citing papers in PubMed, 2 syntheses or guidelines pooled it, 22 citations in OpenAlex.
- Artificial intelligence approaches for schizophrenia prediction and its biomarkers using medical imaging data.Frontiers in psychiatry · 2026Pooled it
- Dysconnectivity of Multiple Brain Networks in Schizophrenia: A Meta-Analysis of Resting-State Functional Connectivity.Frontiers in psychiatry · 2019Pooled it
- Functional Connectivity Biomarkers in Schizophrenia.Advances in neurobiology · 2024Review
- A method for capturing dynamic spectral coupling in resting fMRI reveals domain-specific patterns in schizophrenia.Frontiers in neuroscience · 2023Article
- Reduced homotopic interhemispheric connectivity in psychiatric disorders: evidence for both transdiagnostic and disorder specific features.Psychoradiology · 2022Review
- Schizophrenia: A Survey of Artificial Intelligence Techniques Applied to Detection and Classification.International journal of environmental research and public health · 2021Review
- Increased Homotopic Connectivity in the Prefrontal Cortex Modulated by Olanzapine Predicts Therapeutic Efficacy in Patients with Schizophrenia.Neural plasticity · 2021Observational
- EEG Source Network for the Diagnosis of Schizophrenia and the Identification of Subtypes Based on Symptom Severity-A Machine Learning Approach.Journal of clinical medicine · 2020Article
- The homotopic connectivity of the functional brain: a meta-analytic approach.Scientific reports · 2019Article
- Towards artificial intelligence in mental health by improving schizophrenia prediction with multiple brain parcellation ensemble-learning.NPJ schizophrenia · 2019Article
- Research Progress in Biological Studies of Schizophrenia in China in 2017.Shanghai archives of psychiatry · 2018Review
- Decreased Resting-State Interhemispheric Functional Connectivity Correlated with Neurocognitive Deficits in Drug-Naive First-Episode Adolescent-Onset Schizophrenia.The international journal of neuropsychopharmacology · 2018Article
- Voxel-Mirrored Homotopic Connectivity of Resting-State Functional Magnetic Resonance Imaging in Blepharospasm.Frontiers in psychology · 2018Article
Corrections and comments
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Authors and funding
7 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Family-based case-control design is rarely used but powerful to reduce the confounding effects of environmental factors on schizophrenia. Twenty-eight first-episode, drug-naive patients with schizophrenia, 28 family-based controls (FBC), and 40 healthy controls (HC) underwent resting-state functional MRI. Voxel-mirrored homotopic connectivity (VMHC), receiver operating characteristic curve (ROC), and support vector machine (SVM) were used to process the data. Compared with the FBC, the patients showed lower VMHC in the precuneus, fusiform gyrus/cerebellum lobule VI, and lingual gyrus/cerebellum lobule VI. The patients exhibited lower VMHC in the precuneus relative to the HC. ROC analysis exhibited that the VMHC values in these brain regions might not be ideal biomarkers to distinguish the patients from the FBC/HC. However, SVM analysis indicated that a combination of VMHC values in the precuneus and lingual gyrus/cerebellum lobule VI might be used as a potential biomarker to distinguish the patients from the FBC with a sensitivity of 96.43%, a specificity of 89.29%, and an accuracy of 92.86%. Results suggested that patients with schizophrenia have decreased homotopic connectivity in the motor and low level sensory processing regions. Neuroimaging studies can adopt family-based case-control design as a viable option to reduce the confounding effects of environmental factors on schizophrenia.
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