ArticleEBioMedicine2017
Amphiregulin Antibody and Reduction of Axial Elongation in Experimental Myopia.
Article in EBioMedicine, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
18 citing papers in PubMed, 42 citations in OpenAlex.
- Safety and pharmacokinetics of intravitreally repeatedly injected panitumumab in non-human primates - a study performed under good laboratory practice.BMC ophthalmology · 2026Article
- Aqueous humour concentrations of HB-EGF, EGF and VEGF-A and axial length in humans.Acta ophthalmologica · 2025Article
- Topical Application of Everolimus Attenuates Lens-Induced Myopia Through mTORC1 Suppression.Investigative ophthalmology & visual science · 2025Article
- mTORC1 Signaling and Negative Lens-Induced Axial Elongation.Investigative ophthalmology & visual science · 2023Article
- Intravitreal injection of fibrillin 2 (Fbn2) recombinant protein for therapy of retinopathy in a retina-specific Fbn2 knock-down mouse model.Scientific reports · 2023Article
- Intravitreal Short-Hairpin RNA Attenuated Adeno-Associated Virus-Induced Knockdown of Amphiregulin and Axial Elongation in Experimental Myopia.Investigative ophthalmology & visual science · 2023Article
- Reduction of experimental ocular axial elongation by neuregulin-1 antibody.Frontiers in medicine · 2023Article
- Safety and tolerability of intravitreal cetuximab in young and adult rabbits.Scientific reports · 2022Article
- Epiregulin, epigen and betacellulin antibodies and axial elongation in young guinea pigs with lens-induced myopization.BMC ophthalmology · 2022Article
- Intraocular Amphiregulin antibody and axial elongation in nonhuman primates.Frontiers in ophthalmology · 2022Article
- Compatibility of intravitreally applied epidermal growth factor and amphiregulin.International ophthalmology · 2021Article
- Altered Expression of GJD2 Messenger RNA and the Coded Protein Connexin 36 in Negative Lens-induced Myopia of Guinea Pigs.Optometry and vision science : official publication of the American Academy of Optometry · 2020Article
- Correlation of axial length and myopic macular degeneration to levels of molecular factors in the aqueous.Scientific reports · 2019Article
- [Epidemiology and anatomy of myopia].Der Ophthalmologe : Zeitschrift der Deutschen Ophthalmologischen Gesellschaft · 2019Review
- Ocular size and shape in lens-induced Myopization in young Guinea pigs.BMC ophthalmology · 2019Article
- Update in myopia and treatment strategy of atropine use in myopia control.Eye (London, England) · 2019Review
- Allergic Conjunctivitis-induced Retinal Inflammation Promotes Myopia Progression.EBioMedicine · 2018Article
- Bruch´s membrane thickness in relationship to axial length.PloS one · 2017Article
Corrections and comments
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Authors and funding
10 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
To examine the mechanism of ocular axial elongation in myopia, guinea pigs (age: 2-3weeks) which either underwent unilateral or bilateral lens-induced myopization (group 1) or which were primarily myopic at baseline (group 2) received unilateral intraocular injections of amphiregulin antibody (doses: 5, 10, or 15μg) three times in intervals of 9days. A third group of emmetropic guinea pigs got intraocular unilateral injections of amphiregulin (doses: 0.25, 0.50 or 1.00ng, respectively). In each group, the contralateral eyes received intraocular injections of Ringer's solution. In intra-animal inter-eye comparison and intra-eye follow-up comparison in groups 1 and 2, the study eyes as compared to the contralateral eyes showed a dose-dependent reduction in axial elongation. In group 3, study eyes and control eyes did not differ significantly in axial elongation. Immunohistochemistry revealed amphiregulin labelling at the retinal pigment epithelium in eyes with lens-induced myopization and Ringer's solution injection, but not in eyes with amphiregulin antibody injection. Intraocular injections of amphiregulin-antibody led to a reduction of lens-induced axial myopic elongation and of the physiological eye enlargement in young guinea pigs. In contrast, intraocularly injected amphiregulin in a dose of ≤1ng did not show a significant effect. Amphiregulin may be one of several essential molecular factors for axial elongation.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.