Observational studySurgery for obesity and related diseases : official journal of the American Society for Bariatric Surgery2017
Endometrial cancer associated biomarkers in bariatric surgery candidates: exploration of racial differences.
Observational study in Surgery for obesity and related diseases : official journal of the American Society for Bariatric Surgery, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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3 citing papers in PubMed, 6 citations in OpenAlex.
- Inflammatory biomarker in adipose stem cells of women with endometrial cancer.Biomarkers in medicine · 2018Trial
- Review
- Changes in inflammatory endometrial cancer risk biomarkers in individuals undergoing surgical weight loss.Gynecologic oncology · 2017Article
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8 authors at 2 institutions in 1 country.
Funding
Abstract
backgroundObesity is the main risk factor for endometrial cancer (EC), the most common gynecologic malignancy in the United States. A number of potential risk biomarkers have been associated with EC development, including altered proinflammatory cytokines, chemokines, and adipokines.
objectivesThe overarching aim of this research is to investigate racial differences in the expression of EC-associated biomarkers among bariatric surgery candidates.
settingTertiary academic medical center
methodsBlood samples were collected from 175 women aged 18 to 72 (mean age: 42.93; standard deviation 11.66), before bariatric surgery. Levels of biomarkers associated with obesity and EC risk were measured using xMAP immunoassays. Wilcoxon rank sum and Fisher's exact tests were utilized to compare biomarker and demographic variables between African American and European American women. Linear regression models, adjusted for menopause status and diabetes, were utilized to identify factors associated with biomarker levels.
resultsWhen the biomarker levels were compared by race, insulin-like growth factor-binding protein 1 and adiponectin were significantly lower in African American women (P<.05), whereas estradiol was significantly higher in African American women (P<.05). Linear regression models found that race significantly predicted insulin-like growth factor binding protein 1, adiponectin, resistin, and interleukin-1 receptor alpha expression levels, menopause status and diabetes status were significantly associated with adiponectin and leptin levels, whereas body mass index was significantly associated with leptin, adiponectin, interleukin-1 receptor alpha, and interleukin-6 levels.
conclusionAs one of the first efforts to explore racial differences in EC-associated biomarkers in a cohort of women with severe obesity, this study found several significant differences that should be further explored in large-scale studies.
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