ArticleJournal of Ayurveda and integrative medicine
Polyphenol-rich fraction of Parquetina nigrescens mitigates dichlorvos-induced neurotoxicity and apoptosis.
Article in Journal of Ayurveda and integrative medicine. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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5 citing papers in PubMed.
- The Complicity of DAAM1, PTMA, RSPH6A, and Steroidogenic Genes in the Fertility of Male Rats Exposed to Cadmium During Gestation and Lactation: Attenuation by PREOG.Reproductive sciences (Thousand Oaks, Calif.) · 2025Article
- The Role of Steroidogenic Expression, Apoptotic, and Inflammatory Mediators in Polyphenol-Rich Extract ofVeterinary medicine international · 2025Article
- Quercetin-3-O-β-D-Glucopyranoside-Rich Fraction fromToxics · 2022Article
- "A Review ofEvidence-based complementary and alternative medicine : eCAM · 2022Review
- Evaluation of the Acute Hepatoprotective Potential of Hydroethanolic Extract ofJournal of toxicology · 2020Article
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Abstract
backgroundParquetina nigrescens (Afzel.) Bullock of the family Asclepiadaceae is known for its antioxidant effects with wide range of uses in Southwestern Nigeria especially in traditional medicine. This study was undertaken to explore if polyphenol-rich fraction (prf) from P. nigrescens will ameliorate dichlorvos-induced neurotoxicity and apoptosis. The exploration utilized evaluation of markers of oxidative stress, apoptosis and serum acetylcholinesterase (AchE) levels.
methodsForty Wistar rats randomly placed in four groups were utilized for the study. Animals in Group A received corn oil, group B- dichlorvos (16 mg/kg), groups C and D- dichlorvos + 100 and 200 mg/kg prf of P. nigrescens respectively. Markers of oxidative stress, antioxidants and apoptosis were assessed in the serum and brain tissues using biochemical assay and immunohistochemistry.
resultsExposure to dichlorvos caused significant decreases in AchE, catalase, superoxide dismutase, glutathione peroxidase (GPx) and increases in hydrogen peroxide (H
conclusionThis study showed that dichlorvos caused cellular and tissue neurotoxicity by inhibiting AchE activity, induced oxidative stress and apoptosis in rats with prominent effects on the cerebellum than cerebrum. The prf of P. nigrescens showed amelioration of neurotoxicity by its antioxidative and antiapoptotic properties in rats exposed to dichlorvos.
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