ArticleNeurobiology of aging2017
Genetics of early-onset Parkinson's disease in Finland: exome sequencing and genome-wide association study.
Article in Neurobiology of aging, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.
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Who cites it
32 citing papers in PubMed, 49 citations in OpenAlex.
- Article
- The APOE ε4 allele affects the survival of patients with Parkinson's disease independent of dementia.Journal of translational medicine · 2025Article
- Identification of Novel Genetic Loci for Parkinson's Disease Using Whole-Exome and Whole-Genome Sequencing.Psychiatry and clinical psychopharmacology · 2025Article
- Research on Prediction of Multiple Degenerative Diseases and Biomarker Screening Based on DNA Methylation.International journal of molecular sciences · 2025Article
- A severe neurodegenerative disease with Lewy bodies and a mutation in the glucocerebrosidase gene.NPJ Parkinson's disease · 2023Article
- Transcriptome analysis of the adenoma-carcinoma sequences identifies novel biomarkers associated with development of canine colorectal cancer.Frontiers in veterinary science · 2023Article
- A multicenter study of genetic testing for Parkinson's disease in the clinical setting.NPJ Parkinson's disease · 2022Article
- Article
- Biallelic expansion in RFC1 as a rare cause of Parkinson's disease.NPJ Parkinson's disease · 2022Article
- Genetic Analysis of Patients With Early-Onset Parkinson's Disease in Eastern China.Frontiers in aging neuroscience · 2022Article
- The Big Picture of Neurodegeneration: A Meta Study to Extract the Essential Evidence on Neurodegenerative Diseases in a Network-Based Approach.Frontiers in aging neuroscience · 2022Article
- Genetics in parkinson's disease: From better disease understanding to machine learning based precision medicine.Frontiers in molecular medicine · 2022Review
- Molecular epidemiology of hereditary ataxia in Finland.BMC neurology · 2021Article
- Review
- A glimpse of the genetics of young-onset Parkinson's disease in Central Asia.Molecular genetics & genomic medicine · 2021Article
- Article
- Machine Learning Identifies Six Genetic Variants and Alterations in the Heart Atrial Appendage as Key Contributors to PD Risk Predictivity.Frontiers in genetics · 2021Article
- Characterizing the Expression Patterns of Parkinson's Disease Associated Genes.Frontiers in neuroscience · 2021Article
- Gene4PD: A Comprehensive Genetic Database of Parkinson's Disease.Frontiers in neuroscience · 2021Article
- Parkin is the most common causative gene in a cohort of mainland Chinese patients with sporadic early-onset Parkinson's disease.Brain and behavior · 2020Article
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Authors and funding
9 authors at 4 institutions in 3 countries.
Funding
Abstract
Several genes and risk factors are associated with Parkinson's disease (PD). Although many of the genetic markers belong to a common pathway, a unifying pathogenetic mechanism is yet to be found. Also, missing heritability analyses have estimated that only part of the genetic influence contributing to PD has been found. Here, we carried out whole-exome sequencing (WES) on 438 Finnish patients with early-onset PD. We also reanalyzed previous data from genome-wide association studies (GWAS) on the same cohort. Variants in the CEL gene/locus were associated with PD in both GWAS and WES analysis. Exome-wide gene-based association tests also identified the MPHOSPH10, TAS2R19, and SERPINA1 genes in the discovery data set (p < 2.5E-6). MPHOSPH10 had estimated odds ratio (OR) of 1.53, and the rs141620200 variant in SERPINA1 had OR of 1.27. We identified several candidate genes, but further investigation is required to determine the role of these genes in PD.
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