ArticleBiophysical journal2017
Dynamic Sampling and Information Encoding in Biochemical Networks.
Article in Biophysical journal, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
13 citing papers in PubMed.
- Dynamics of positional information in the vertebrate neural tube.Journal of the Royal Society, Interface · 2024Article
- Understanding How Cells Probe the World: A Preliminary Step towards Modeling Cell Behavior?International journal of molecular sciences · 2023Article
- Quantifying information of intracellular signaling: progress with machine learning.Reports on progress in physics. Physical Society (Great Britain) · 2022Review
- Escherichia coli chemotaxis is information limited.Nature physics · 2021Article
- The mechanics and dynamics of cancer cells sensing noisy 3D contact guidance.Proceedings of the National Academy of Sciences of the United States of America · 2021Article
- Information transmission from NFkB signaling dynamics to gene expression.PLoS computational biology · 2020Article
- Estimating information in time-varying signals.PLoS computational biology · 2019Article
- Exploring the information transmission properties of noise-induced dynamics: application to glioma differentiation.BMC bioinformatics · 2019Article
- Information-theoretic analysis of multivariate single-cell signaling responses.PLoS computational biology · 2019Article
- Limits to the rate of information transmission through the MAPK pathway.Journal of the Royal Society, Interface · 2019Article
- Cellular and Network Mechanisms for Temporal Signal Propagation in a Cortical Network Model.Frontiers in computational neuroscience · 2019Article
- Intrinsic limits of information transmission in biochemical signalling motifs.Interface focus · 2018Article
- NF-κB Dynamics Discriminate between TNF Doses in Single Cells.Cell systems · 2017Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Cells use biochemical networks to translate environmental information into intracellular responses. These responses can be highly dynamic, but how the information is encoded in these dynamics remains poorly understood. Here, we investigate the dynamic encoding of information in the ATP-induced calcium responses of fibroblast cells, using a vectorial, or multi-time-point, measure from information theory. We find that the amount of extracted information depends on physiological constraints such as the sampling rate and memory capacity of the downstream network, and it is affected differentially by intrinsic versus extrinsic noise. By comparing to a minimal physical model, we find, surprisingly, that the information is often insensitive to the detailed structure of the underlying dynamics, and instead the decoding mechanism acts as a simple low-pass filter. These results demonstrate the mechanisms and limitations of dynamic information storage in cells.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.