ArticleBiophysical journal2017
Optical Phase Measurements of Disorder Strength Link Microstructure to Cell Stiffness.
Article in Biophysical journal, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
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Who cites it
28 citing papers in PubMed.
- Enhanced detection of malaria infected red blood cells through phase driven classification.Scientific reports · 2025Article
- Utilizing quantitative phase microscopy to localize fluorescence in three dimensions via the transport of intensity equation.Optics letters · 2024Article
- High-resolution assessment of multidimensional cellular mechanics using label-free refractive-index traction force microscopy.Communications biology · 2024Article
- Contributions of viral oncogenes of HPV-18 and hypoxia to oxidative stress and genetic damage in human keratinocytes.Scientific reports · 2023Article
- Rapid and precise tracking of water influx and efflux across cell membranes induced by a pulsed electric field.Biomedical optics express · 2023Article
- Multiscale optical phase fluctuations link disorder strength and fractal dimension of cell structure.Biophysical journal · 2023Article
- Review
- Quantitative phase velocimetry measures bulk intracellular transport of cell mass during the cell cycle.Scientific reports · 2022Article
- Live-dead assay on unlabeled cells using phase imaging with computational specificity.Nature communications · 2022Article
- Viscoelasticity, Like Forces, Plays a Role in Mechanotransduction.Frontiers in cell and developmental biology · 2022Review
- Synthetic aperture interference light (SAIL) microscopy for high-throughput label-free imaging.Applied physics letters · 2021Article
- Article
- Single Cell Analysis of Stored Red Blood Cells Using Ultra-High Throughput Holographic Cytometry.Cells · 2021Article
- Label-free SARS-CoV-2 detection and classification using phase imaging with computational specificity.Light, science & applications · 2021Article
- Cell viscoelasticity is linked to fluctuations in cell biomass distributions.Scientific reports · 2020Article
- Simple adaptive mobile phone screen illumination for dual phone differential phase contrast (DPDPC) microscopy.Biomedical optics express · 2019Article
- Shear Modulus Measurement by Quantitative Phase Imaging and Correlation with Atomic Force Microscopy.Biophysical journal · 2019Article
- A Toolbox for Organelle Mechanobiology Research-Current Needs and Challenges.Micromachines · 2019Article
- Studying nucleic envelope and plasma membrane mechanics of eukaryotic cells using confocal reflectance interferometric microscopy.Nature communications · 2019Article
- Light scattering methods for tissue diagnosis.Optica · 2019Article
Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
There have been sustained efforts on the part of cell biologists to understand the mechanisms by which cells respond to mechanical stimuli. To this end, many rheological tools have been developed to characterize cellular stiffness. However, measurement of cellular viscoelastic properties has been limited in scope by the nature of most microrheological methods, which require direct mechanical contact, applied at the single-cell level. In this article, we describe, to our knowledge, a new analysis approach for quantitative phase imaging that relates refractive index variance to disorder strength, a parameter that is linked to cell stiffness. Significantly, both disorder strength and cell stiffness are measured with the same phase imaging system, presenting a unique alternative for label-free, noncontact, single-shot imaging of cellular rheologic properties. To demonstrate the potential applicability of the technique, we measure phase disorder strength and shear stiffness across five cellular populations with varying mechanical properties and demonstrate an inverse relationship between these two parameters. The existence of this relationship suggests that predictions of cell mechanical properties can be obtained from examining the disorder strength of cell structure using this, to our knowledge, novel, noncontact technique.
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