Evidence map›Paper›PMID 28256223›Full record

ArticleBiophysical journal2017

Orientation and Location of the Cyclotide Kalata B1 in Lipid Bilayers Revealed by Solid-State NMR.

Stephan L Grage, Marc-Antoine Sani, Olivier Cheneval, Sónia Troeira Henriques, Constantin Schalck, Ralf Heinzmann, Joshua S Mylne, Pavel K Mykhailiuk, Sergii Afonin, Igor V Komarov and 3 more

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biophysical journal, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
1.6field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 24 citations in OpenAlex.

  1. Review
  2. Magnetic Alignment of Polymer Nanodiscs Probed by Solid-State NMR Spectroscopy.Langmuir : the ACS journal of surfaces and colloids · 2020
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 5 institutions in 3 countries.

Stephan L GrageInstitute of Biological Interfaces (IBG-2), Karlsruhe Institute of Technology, Karlsruhe, Germany.
Marc-Antoine SaniSchool of Chemistry, Bio21 Institute, The University of Melbourne, Melbourne, Victoria, Australia.
Olivier ChenevalInstitute for Molecular Bioscience, The University of Queensland, Brisbane, Queensland, Australia.
Sónia Troeira HenriquesInstitute for Molecular Bioscience, The University of Queensland, Brisbane, Queensland, Australia.
Constantin SchalckInstitute of Biological Interfaces (IBG-2), Karlsruhe Institute of Technology, Karlsruhe, Germany.
Ralf HeinzmannInstitute of Biological Interfaces (IBG-2), Karlsruhe Institute of Technology, Karlsruhe, Germany.
Joshua S MylneInstitute for Molecular Bioscience, The University of Queensland, Brisbane, Queensland, Australia.
Pavel K MykhailiukChemistry Department, Taras Shevchenko National University of Kyiv, Kyiv, Ukraine; Enamine Ltd., Kyiv, Ukraine.
Sergii AfoninInstitute of Biological Interfaces (IBG-2), Karlsruhe Institute of Technology, Karlsruhe, Germany.
Igor V KomarovInstitute of High Technologies, Taras Shevchenko National University of Kyiv, Kyiv, Ukraine.
Frances SeparovicSchool of Chemistry, Bio21 Institute, The University of Melbourne, Melbourne, Victoria, Australia.
David J CraikInstitute for Molecular Bioscience, The University of Queensland, Brisbane, Queensland, Australia.
Anne S UlrichInstitute of Biological Interfaces (IBG-2), Karlsruhe Institute of Technology, Karlsruhe, Germany; Institute of Organic Chemistry, Karlsruhe Institute of Technology, Karlsruhe, Germany. Electronic address: anne.ulrich@kit.edu.
Karlsruhe Institute of Technology · DEUniversity of Queensland · AUUniversity of Melbourne · AUEnamine (Ukraine) · UATaras Shevchenko National University of Kyiv · UA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Cyclotides are ultra-stable cyclic disulfide-rich peptides from plants. Their biophysical effects and medically interesting activities are related to their membrane-binding properties, with particularly high affinity for phosphatidylethanolamine lipids. In this study we were interested in understanding the molecular details of cyclotide-membrane interactions, specifically with regard to the spatial orientation of the cyclotide kalata B1 from Oldenlandia affinis when embedded in a lipid bilayer. Our experimental approach was based on the use of solid-state

Indexed as

Amino Acid SequenceCyclotidesLipid BilayersMagnetic Resonance SpectroscopyModels, MolecularOldenlandiaProtein ConformationCyclotideskalata B1Lipid Bilayers

Identifiers

PMID28256223
PMCPMC5340158
OpenAlexW2593564735

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.