Evidence map›Paper›PMID 28256177›Full record

ReviewExpert review of cardiovascular therapy2017

Complications during pregnancy and fetal development: implications for the occurrence of chronic kidney disease.

Ashley D Newsome, Gwendolyn K Davis, Norma B Ojeda, Barbara T Alexander

Open access · greenAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Expert review of cardiovascular therapy, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.8field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 3 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Ashley D Newsomea Departments of Physiology and Biophysics , University of Mississippi Medical Center , Jackson , MS , USA.
Gwendolyn K Davisa Departments of Physiology and Biophysics , University of Mississippi Medical Center , Jackson , MS , USA.
Norma B Ojedab Pediatrics , University of Mississippi Medical Center , Jackson , MS , USA.
Barbara T Alexandera Departments of Physiology and Biophysics , University of Mississippi Medical Center , Jackson , MS , USA.
Jackson Memorial Hospital · USUniversity of Mississippi Medical Center · US

Funding

STRUCTURAL VASCULAR ADAPTATION OF THE MICROCIRCULATIONP01HL051971 · NHLBI · UNIVERSITY OF MISSISSIPPI MEDICAL CENTER · PI RECKELHOFF, JANE F · 1993 to 2018
$39.4M
The role of leptin in autoimmune-associated hypertensionP20GM104357 · NIGMS · UNIVERSITY OF MISSISSIPPI MED CTR · PI HALL, JOHN E · 2013 to 2022
$23.4M
Hypertension and Cardiorenal Research Training ProgramT32HL105324 · NHLBI · UNIVERSITY OF MISSISSIPPI MED CTR · PI Joey P. Granger · 2010 to 2026
$7.8M
Low birth weight, the kidney, and hypertensionR01HL074927 · NHLBI · UNIVERSITY OF MISSISSIPPI MEDICAL CENTER · PI ALEXANDER, BARBARA T · 2004 to 2013
$3.0M
Low Birth Weight, Blood Pressure, and Kidney DiseaseF30DK112718 · NIDDK · UNIVERSITY OF MISSISSIPPI MED CTR · PI NEWSOME, ASHLEY DENISE · 2016 to 2018
$108k
CARDIOVASCULAR/RENAL MECHANISMS OF HYPERTENSIONF32HL010137 · NHLBI · UNIVERSITY OF MISSISSIPPI MEDICAL CENTER · PI ALEXANDER, BARBARA T · 1999 to 2001
$80k
NHLBI NIH HHS F32 HL010137NHLBI NIH HHS P01 HL051971NHLBI NIH HHS R01 HL074927NHLBI NIH HHS T32 HL105324NIDDK NIH HHS F30 DK112718NIGMS NIH HHS P20 GM104357
6 · The paper itself

Abstract

introductionNumerous epidemiological studies indicate an inverse association between birth weight and the risk for chronic kidney disease. Areas covered: Historically, the first studies to address the developmental origins of chronic disease focused on the inverse relationship between birth weight and blood pressure. A reduction in nephron number was a consistent finding in low birth weight individuals and experimental models of developmental insult. Recent studies indicate that a congenital reduction in renal reserve in conjunction with an increase in blood pressure that has its origins in fetal life increases vulnerability to renal injury and disease. Expert commentary: Limited experimental studies have investigated the mechanisms that contribute to the developmental origins of kidney disease. Several studies suggest that enhanced susceptibility to renal injury following a developmental insult is altered by sex and age. More in-depth studies are needed to clarify how low birth weight contributes to enhanced renal risk, and how sex and age influence this adverse relationship.

Indexed as

Birth WeightBlood PressureFemaleFetal DevelopmentHumansHypertensionInfant, Low Birth WeightInfant, NewbornKidneyNephronsPregnancyRenal Insufficiency, Chronicchronic kidney diseaseDevelopmental originshypertensionIUGRlow birth weightnephron number

Identifiers

PMID28256177
PMCPMC5543771
OpenAlexW2587474501

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.