Evidence map›Paper›PMID 28255928›Full record

SynthesisJournal of genetic counseling2017

A Systematic Review of Randomized Controlled Trials to Assess Outcomes of Genetic Counseling.

Barbara A Athens, Samantha L Caldwell, Kendall L Umstead, Philip D Connors, Ethan Brenna, Barbara B Biesecker

Abstract readSystematic Review
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Journal of genetic counseling, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 55 papers, 6 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
55citing papers in PubMed, 6 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

55 citing papers in PubMed, 6 syntheses or guidelines pooled it.

  1. Pooled it
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  3. Decision coaching for people making healthcare decisions.The Cochrane database of systematic reviews · 2021
    Pooled it
  4. Germline and Somatic Tumor Testing in Epithelial Ovarian Cancer: ASCO Guideline.Journal of clinical oncology : official journal of the American Society of Clinical Oncology · 2020
    Pooled it
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  6. Personal utility in genomic testing: a systematic literature review.European journal of human genetics : EJHG · 2017
    Pooled it
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Barbara A AthensSocial and Behavioral Research Branch, National Human Genome Research Institute, National Institutes of Health, 31 Center Dr, MSC 2073, Bethesda, MD, 20892-2073, USA.
Samantha L CaldwellSocial and Behavioral Research Branch, National Human Genome Research Institute, National Institutes of Health, 31 Center Dr, MSC 2073, Bethesda, MD, 20892-2073, USA.
Kendall L UmsteadSocial and Behavioral Research Branch, National Human Genome Research Institute, National Institutes of Health, 31 Center Dr, MSC 2073, Bethesda, MD, 20892-2073, USA.
Philip D ConnorsSocial and Behavioral Research Branch, National Human Genome Research Institute, National Institutes of Health, 31 Center Dr, MSC 2073, Bethesda, MD, 20892-2073, USA.
Ethan BrennaSocial and Behavioral Research Branch, National Human Genome Research Institute, National Institutes of Health, 31 Center Dr, MSC 2073, Bethesda, MD, 20892-2073, USA.
Barbara B BieseckerSocial and Behavioral Research Branch, National Human Genome Research Institute, National Institutes of Health, 31 Center Dr, MSC 2073, Bethesda, MD, 20892-2073, USA. barbarab@mail.nih.gov.

Funding

Interventions in Genetic CounselingZIAHG200317 · NHGRI · NATIONAL HUMAN GENOME RESEARCH INSTITUTE · PI BIESECKER, BARBARA BOWLES · 2009 to 2018
$7.6M
Interventions in Genetic CounselingZ01HG200317 · NHGRI · NATIONAL HUMAN GENOME RESEARCH INSTITUTE · PI BIESECKER, BARBARA BOWLES · 2004 to 2008
$1.7M
Intramural NIH HHS Z01 HG200317NHGRI NIH HHS Intramural Research funds
6 · The paper itself

Abstract

With the advancements in precision medicine and health care reform, it is critical that genetic counseling practice respond to emerging evidence to maximize client benefit. The objective of this review was to synthesize evidence on outcomes from randomized controlled trials (RCTs) of genetic counseling to inform clinical practice. Seven databases were searched in conducting this review. Studies were selected for inclusion if they were: (a) RCTs published from 1990 to 2015, and (b) assessed a direct outcome of genetic counseling. Extracted data included study population, aims, and outcomes. Risk of bias was evaluated using the Cochrane Handbook for Systematic Reviews of Interventions guidelines. A review of 1654 abstracts identified 58 publications of 54 unique RCTs that met inclusion criteria, the vast majority of which were conducted in cancer genetic counseling setting. Twenty-seven publications assessed 'enhancements' to genetic counseling, and 31 publications compared delivery modes. The methodological rigor varied considerably, highlighting the need for attention to quality criteria in RCT design. While most studies assessed several client outcomes hypothesized to be affected by genetic counseling (e.g., psychological wellbeing, knowledge, perceived risk, patient satisfaction), disparate validated and reliable scales and other assessments were often used to evaluate the same outcome(s). This limits opportunity to compare findings across studies. While RCTs of genetic counseling demonstrate enhanced client outcomes in a number of studies and pave the way to evidence-based practice, the heterogeneity of the research questions suggest an important need for more complementary studies with consistent outcome assessments.

Indexed as

Randomized Controlled Trials as TopicGenetic CounselingHumansOutcome Assessment, Health CarePatient SatisfactionEvidence-based practiceGenetic counselingGenetic counseling outcomesGenetics knowledgePatient outcomesPatient satisfactionPsychological wellbeingRandomized controlled trialsRisk perception

Identifiers

PMID28255928
PMCPMC7350655

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.