ArticleClinical and experimental nephrology2017
The clinical and pathological characteristics of nephropathies in connective tissue diseases in the Japan Renal Biopsy Registry (J-RBR).
Article in Clinical and experimental nephrology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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18 citing papers in PubMed, 27 citations in OpenAlex.
- Evaluation of clinicopathological features of renal biopsies in non-lupus rheumatic diseases: a university hospital experience.Renal failure · 2026Article
- Rare case report: a man with rheumatoid arthritis developed membranous nephropathy and ANCA-associated vasculitis successively.BMC nephrology · 2025Article
- Focal segmental glomerulosclerosis in primary Sjögren's syndrome: a rare presentation.Pediatric nephrology (Berlin, Germany) · 2024Article
- Kidney Involvement in Systemic Sclerosis.Journal of personalized medicine · 2022Review
- Anti-MDA5 Antibody-positive Dermatomyositis with Rapidly Progressive Interstitial Pneumonia Presenting with Nephrotic Syndrome during Treatment with Corticosteroids and Cyclosporine.Internal medicine (Tokyo, Japan) · 2022Article
- Serum-negative Sjogren's syndrome with minimal lesion nephropathy as the initial presentation: A case report.World journal of clinical cases · 2022Article
- Glomerulopathy in patients with dermatomyositis in early active disease: clinical, pathological and capillaroscopic manifestations, and response to treatment.Reumatologia · 2022Article
- Renal abnormalities in rheumatoid arthritis: an insight on IgA nephropathy.Rheumatology advances in practice · 2022Article
- Renal disorders in rheumatologic diseases: the spectrum is changing (Part 1: connective tissue diseases).Journal of nephrology · 2021Review
- Membranous nephropathy with masked polyclonal IgG deposits associated with primary Sjögren's syndrome.CEN case reports · 2021Article
- Clinical manifestations of focal segmental glomerulosclerosis in Japan from the Japan Renal Biopsy Registry: age stratification and comparison with minimal change disease.Scientific reports · 2021Article
- The revised version 2018 of the nationwide web-based registry system for kidney diseases in Japan: Japan Renal Biopsy Registry and Japan Kidney Disease Registry.Clinical and experimental nephrology · 2020Article
- Patterns of renal pathology in Chinese patients with systemic sclerosis undergoing renal biopsy at a tertiary medical center.The Journal of international medical research · 2020Article
- Membranous nephropathy caused by rheumatoid arthritis.CEN case reports · 2019Article
- Nephrotic Syndrome due to Focal Segmental Glomerulosclerosis Complicating Sjögren's Syndrome: A Case Report and Literature Review.Case reports in rheumatology · 2019Article
- Renal pathology and clinical associations in systemic sclerosis: a historical cohort study.International journal of general medicine · 2019Article
- Emergence of Smoldering ANCA-associated Glomerulonephritis during the Clinical Course of Mixed Connective Tissue Disease and Sjögren's Syndrome.Internal medicine (Tokyo, Japan) · 2018Article
- AL Amyloidosis in a Patient with Long-Standing Rheumatoid Arthritis: Is there a Link with Autoimmune Disease and Monoclonal Gammopathy of Renal Significance?Indian journal of nephrologyArticle
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5 authors at 4 institutions in 1 country.
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No grant is acknowledged in the PubMed record.
Abstract
backgroundIn connective tissue diseases, a wide variety of glomerular, tubulointerstitial, and vascular lesions of the kidney are observed. Nonetheless, recent information is limited regarding renal lesions in connective tissue diseases, except in systemic lupus erythematosus (SLE).
methodsIn this study, we used a nationwide database of biopsy-confirmed renal diseases in Japan (J-RBR) (UMIN000000618). In total, 20,523 registered patients underwent biopsy between 2007 and 2013; from 110 patients with connective tissue diseases except SLE, we extracted data regarding the clinico-pathological characteristics of the renal biopsy.
resultsOur analysis included patients with rheumatoid arthritis (RA) (n = 52), Sjögren's syndrome (SjS) (n = 35), scleroderma (n = 10), mixed connective tissue disease (MCTD; n = 5), anti-phospholipid syndrome (APS; n = 3), polymyositis/dermatomyositis (PM/DM; n = 1), Behçet's disease (n = 1) and others (n = 3). The clinico-pathological features differed greatly depending on the underlying disease. The major clinical diagnosis was nephrotic syndrome in RA; chronic nephritic syndrome with mild proteinuria and reduced renal function in SjS; rapidly progressive nephritic syndrome in scleroderma. The major pathological diagnosis was membranous nephropathy (MN) and amyloidosis in RA; tubulointerstitial nephritis in SjS; proliferative obliterative vasculopathy in scleroderma; MN in MCTD. In RA, most patients with nephrosis were treated using bucillamine, and showed membranous nephropathy.
conclusionsUsing the J-RBR database, our study revealed that biopsy-confirmed cases of connective tissue diseases such as RA, SjS, scleroderma, and MCTD show various clinical and pathological characteristics, depending on the underlying diseases and the medication used.
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