Surface Engineering of Nanoparticles to Create Synthetic Antibodies.

Linda Chio, Darwin Yang, Markita Landry

Abstract read

In one paragraph

Article in Methods in molecular biology (Clifton, N.J.), 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it

0cells of the map it votes in

4citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

High-throughput evolution of near-infrared serotonin nanosensors.Science advances · 2019
Article
Synthetic probe development for measuring single or few-cell activity and efflux.Methods in enzymology · 2019
Article
Advances in Nanomaterials for Brain Microscopy.Nano research · 2018
Article
Tuning Selectivity of Fluorescent Carbon Nanotube-Based Neurotransmitter Sensors.Sensors (Basel, Switzerland) · 2017
Article

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Linda ChioDepartment of Chemical and Biomolecular Engineering, University of California, Berkeley, CA, USA.

Darwin YangDepartment of Chemical and Biomolecular Engineering, University of California, Berkeley, CA, USA.

Markita LandryDepartment of Chemical and Biomolecular Engineering, University of California, Berkeley, CA, USA. landry@berkeley.edu.

Funding

Single-Molecule Imaging of Biological Trauma:Cytokine-Based Intracellular CommunicationR35GM128922 · NIGMS · UNIVERSITY OF CALIFORNIA BERKELEY · PI LANDRY, MARKITA · 2019 to 2023

$2.0M

Novel optical probe for dopamine release in neural circuitsR21EY029405 · NEI · UNIVERSITY OF CALIFORNIA BERKELEY · PI FELLER, MARLA, LANDRY, MARKITA · 2018 to 2019

$428k

NEI NIH HHS R21 EY029405NIGMS NIH HHS R35 GM128922

6 · The paper itself

Abstract

Surface engineering of nanoparticles has recently emerged as a promising technique for synthetic molecular recognition of biological analytes. In particular, the use of synthetic heteropolymers adsorbed onto the surface of a nanoparticle can yield selective detection of a molecular target. Synthetic molecular recognition has unique advantages in leveraging the photostability, versatility, and exceptional chemical stability of nanomaterials. In particular, single-walled carbon nanotubes (SWNT) exhibit a large Stokes shift and near infrared emission for maximum biological sample transparency. Optical biosensors with high signal transduction and molecular specificity can be synthesized with amphiphilic heteropolymers grafted to SWNT, and discovered by high-throughput screening. Herein, we describe the development and the characterization of surface-engineered nanoparticles, or "synthetic antibodies," for protein detection.

Indexed as

AdsorptionAntibodiesBiosensing TechniquesMicroscopy, FluorescenceNanotubes, CarbonSurface PropertiesAntibodiesNanotubes, CarbonCarbon nanotubesDNA aptamersInfrared fluorescence microscopyNanomaterialsProtein detectionSensorsSynthetic antibodies

Identifiers

PMID28255893

DOI10.1007/978-1-4939-6857-2_23

PMCPMC10461897

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.