Evidence map›Paper›PMID 28255865›Full record

ArticleEuropean journal of drug metabolism and pharmacokinetics2017

Antioxidative and Protective Actions of Apigenin in a Paracetamol-Induced Hepatotoxicity Rat Model.

Aleksandar Rašković, Slobodan Gigov, Ivan Čapo, Milica Paut Kusturica, Boris Milijašević, Sunčica Kojić-Damjanov, Nikola Martić

Registry-linked trialAbstract read
PubMed Publisher
In one paragraph

Article in European journal of drug metabolism and pharmacokinetics, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06560216 (Effects of Supplementation of Cryopreservation Medium With Apigenin on Post-thaw Human Sperm), which is not on this map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
3.1field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06560216 nacompletednot on this mapstarted 2024, after this paper: background citation

Effects of Supplementation of Cryopreservation Medium With Apigenin on Post-thaw Human Sperm

TypeinterventionalSponsorChulalongkorn UniversityRan2024 to 2025Enrolled57ConditionsHealthyArmsApigenin
3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 47 citations in OpenAlex.

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  13. Resveratrol supplementation improves metabolic control in rats with induced hyperlipidemia and type 2 diabetes.Saudi pharmaceutical journal : SPJ : the official publication of the Saudi Pharmaceutical Society · 2019
    Article
  14. The hepatoprotective activities ofFood science & nutrition · 2019
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Aleksandar RaškovićFaculty of Medicine, Novi Sad, Serbia.
Slobodan GigovFaculty of Medicine, Novi Sad, Serbia.
Ivan ČapoFaculty of Medicine, Novi Sad, Serbia.
Milica Paut KusturicaFaculty of Medicine, Novi Sad, Serbia. milicakusturica@uns.ac.rs.
Boris MilijaševićFaculty of Medicine, Novi Sad, Serbia.
Sunčica Kojić-DamjanovFaculty of Medicine, Novi Sad, Serbia.
Nikola MartićFaculty of Medicine, Novi Sad, Serbia.
University of Novi Sad · RS

Funding

Provincial Secretariat for Science and Technological Development, Autonomous Province of Vojvodina No. 114-451-698/2015-02
6 · The paper itself

Abstract

BACKGROUND AND

objectivesApigenin is known to have various pharmacological properties without causing significant toxicity; however, hepatoprotective effect of apigenin is not often reported. The aim of our study was to investigate if the alterations in lipid peroxidation and antioxidant status are in favor to prove the efficacy of apigenin against paracetamol-induced hepatotoxicity.

methodsThe effect of apigenin on paracetamol-induced hepatotoxicity in rats was examined by determining biochemical parameters, histological assessment and oxidative status in liver homogenates.

resultsThe treatment of animals with both apigenin and paracetamol attenuates the parameters of hepatotoxicity, especially for ALT and ALP activity which was significantly lower compared to groups of animals treated with saline and paracetamol. Hepatotoxicity induced by toxic dose of paracetamol was revealed also by notable histopathological alterations, which were not observed in the group treated with paracetamol together with apigenin. Apigenin also prevented paracetamol-induced increase in malondialdehyde (MDA) level. The activities of both CAT (catalase) and GR (glutathione reductase) enzymes after the toxic dose of paracetamol were significantly increased in the liver homogenates, compared to control group. Apigenin reversed these parameters near to values of control group.

conclusionsThe result of our study indicates that apigenin inhibits the level of lipid peroxidation and significantly increases the enzyme antioxidant defense mechanisms in paracetamol-induced hepatotoxicity in rats.

Indexed as

AcetaminophenAlanine TransaminaseAnimalsAntioxidantsApigeninAspartate AminotransferasesChemical and Drug Induced Liver InjuryDisease Models, AnimalGlutathioneLipid PeroxidationLiverMaleOxidative StressPhytotherapyProtective AgentsRatsAcetaminophenAlanine TransaminaseAntioxidantsApigeninAspartate AminotransferasesGlutathioneProtective AgentsApigeninGlutathione ReductaseLiver HomogenateParacetamolToxic Dose

Identifiers

PMID28255865
OpenAlexW2593927181

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.