Evidence map›Paper›PMID 28255752›Full record

SynthesisClinical oral investigations2017

Is there enough evidence to use botulinum toxin injections for bruxism management? A systematic literature review.

Giancarlo De la Torre Canales, Mariana Barbosa Câmara-Souza, Camilla Fraga do Amaral, Renata Cunha Matheus Rodrigues Garcia, Daniele Manfredini

Abstract readSystematic Review
PubMed Publisher
In one paragraph

Synthesis in Clinical oral investigations, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers, 6 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
33citing papers in PubMed, 6 pooled it
12.3field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

33 citing papers in PubMed, 6 syntheses or guidelines pooled it, 88 citations in OpenAlex.

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  8. Does the Use of Botulinum Toxin in Treatment of Myofascial Pain Disorder of the Masseters and Temporalis Muscles Reduce Pain, Improve Function, or Enhance Quality of Life?Journal of oral and maxillofacial surgery : official journal of the American Association of Oral and Maxillofacial Surgeons · 2024
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  20. Comparison of the efficacy of occlusal splint and botulinum toxin therapies in patients with temporomandibular disorders with sleep bruxism.Journal of orofacial orthopedics = Fortschritte der Kieferorthopadie : Organ/official journal Deutsche Gesellschaft fur Kieferorthopadie · 2024
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 2 countries.

Giancarlo De la Torre CanalesDepartment of Prosthodontics and Periodontology, Piracicaba Dental School, University of Campinas, Avenida Limeira, no. 901, Bairro Areião, Piracicaba, SP, 13414-903, Brazil.
Mariana Barbosa Câmara-SouzaDepartment of Prosthodontics and Periodontology, Piracicaba Dental School, University of Campinas, Avenida Limeira, no. 901, Bairro Areião, Piracicaba, SP, 13414-903, Brazil.
Camilla Fraga do AmaralDepartment of Prosthodontics and Periodontology, Piracicaba Dental School, University of Campinas, Avenida Limeira, no. 901, Bairro Areião, Piracicaba, SP, 13414-903, Brazil.
Renata Cunha Matheus Rodrigues GarciaDepartment of Prosthodontics and Periodontology, Piracicaba Dental School, University of Campinas, Avenida Limeira, no. 901, Bairro Areião, Piracicaba, SP, 13414-903, Brazil. regarcia@fop.unicamp.br.
Daniele ManfrediniTemporomandibular Disorders Clinic, School of Dentistry, University of Padova, Padova, Italy.
Universidade Estadual de Campinas (UNICAMP) · BRUniversity of Padua · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveThe objective of the study was to conduct a systematic review of the literature assessing the effects of botulinum toxin (BoNT-A) injections in the management of bruxism. MATERIALS AND

methodsSearch for articles involved the PubMed, Scopus, Web of Science, Embase, Cochrane, Scielo and Lilacs databases. Specific terms were used and the search carried out from 1980 to March 2016 by three independent researchers. Randomized controlled studies (RCTs), prospective and before-after studies that applied BoNT-A at the masseter and/or temporalis muscles were included.

resultsThree RCTs and two uncontrolled before-after studies out of 904 identified citations were included in this review. All five articles dealt with sleep bruxism and featured a small sample size. None of them was about awake bruxism. Two randomized clinical trials were double-blinded, with a control group using saline solution. Two studies used polysomnography/electromyography for sleep bruxism diagnosis, whilst others were based on history taking and clinical examination. All studies using subjective evaluations for pain and jaw stiffness showed positive results for the BoNT-A treatment. In contrast, the two studies using objective evaluations did not demonstrate any reduction in bruxism episodes, but a decrease in the intensity of muscles contractions.

conclusionDespite the paucity of works on the topic, BoNT-A seems to be a possible management option for sleep bruxism, minimizing symptoms and reducing the intensity of muscle contractions, although further studies are necessary especially as far as the treatment indications for bruxism itself is concerned. CLINICAL RELEVANCE: BoNT-A has been increasingly diffused in dentistry over recent years, being also used for pain management in patients with bruxism. Nonetheless, there is no consensus about its effects in this disorder.

Indexed as

Botulinum Toxins, Type ABruxismElectromyographyHumansInjectionsMasseter MuscleNeuromuscular AgentsPolysomnographyTemporal MuscleBotulinum Toxins, Type ANeuromuscular AgentsBotulinum toxins type ABruxismFacial painSleep bruxismTreatment

Identifiers

PMID28255752
OpenAlexW2593748540

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.