Evidence map›Paper›PMID 28255667›Full record

ArticleStrahlentherapie und Onkologie : Organ der Deutschen Rontgengesellschaft ... [et al]2017

Framework for radiation pneumonitis risk stratification based on anatomic and perfused lung dosimetry.

Gurleen Dhami, Jing Zeng, Hubert J Vesselle, Paul E Kinahan, Robert S Miyaoka, Shilpen A Patel, Ramesh Rengan, Stephen R Bowen

Abstract readControlled Clinical Trial
In one paragraph

Article in Strahlentherapie und Onkologie : Organ der Deutschen Rontgengesellschaft ... [et al], 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

22 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. Trial
  4. Is prone free breathing better than supine deep inspiration breath-hold for left whole-breast radiotherapy? A dosimetric analysis.Strahlentherapie und Onkologie : Organ der Deutschen Rontgengesellschaft ... [et al] · 2021
    Trial
  5. Trial
  6. Review
  7. Review
  8. Article
  9. Observational
  10. Article
  11. Article
  12. Biology of Radiation-Induced Lung Injury.Seminars in radiation oncology · 2021
    Review
  13. Review
  14. Image-based lung functional radiotherapy planning for non-small cell lung cancer.Strahlentherapie und Onkologie : Organ der Deutschen Rontgengesellschaft ... [et al] · 2020
    Article
  15. Review
  16. Article
  17. Article
  18. Prognostic factors in stereotactic body radiotherapy of lung metastases.Strahlentherapie und Onkologie : Organ der Deutschen Rontgengesellschaft ... [et al] · 2018
    Article
  19. Article
  20. Occurrence of pneumonitis following radiotherapy of breast cancer - A prospective study.Strahlentherapie und Onkologie : Organ der Deutschen Rontgengesellschaft ... [et al] · 2018
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Gurleen DhamiDepartment of Radiation Oncology, University of Washington School of Medicine, 98195, Seattle, WA, USA.
Jing ZengDepartment of Radiation Oncology, University of Washington School of Medicine, 98195, Seattle, WA, USA.
Hubert J VesselleDepartment of Radiology, University of Washington School of Medicine, 98195, Seattle, WA, USA.
Paul E KinahanDepartment of Radiology, University of Washington School of Medicine, 98195, Seattle, WA, USA.
Robert S MiyaokaDepartment of Radiology, University of Washington School of Medicine, 98195, Seattle, WA, USA.
Shilpen A PatelDepartment of Radiation Oncology, University of Washington School of Medicine, 98195, Seattle, WA, USA.
Ramesh RenganDepartment of Radiation Oncology, University of Washington School of Medicine, 98195, Seattle, WA, USA.
Stephen R BowenDepartment of Radiation Oncology, University of Washington School of Medicine, 98195, Seattle, WA, USA. srbowen@uw.edu.

Funding

Translational Bioimaging Core Shared ResourceP30CA015704 · NCI · FRED HUTCHINSON CANCER RESEARCH CENTER · PI Marian Esvelt · 1985 to 2026
$296.4M
Personalized radiation therapy through functional lung avoidance and response-adaptive dose escalation: utilizing multimodal molecular imaging to improve the therapeutic ratioR01CA204301 · NCI · UNIVERSITY OF WASHINGTON · PI BOWEN, STEPHEN R., ZENG, JING · 2016 to 2020
$2.3M
NCI NIH HHS P30 CA015704NCI NIH HHS R01 CA204301
6 · The paper itself

Abstract

purposeTo design and apply a framework for predicting symptomatic radiation pneumonitis in patients undergoing thoracic radiation, using both pretreatment anatomic and perfused lung dose-volume parameters. MATERIALS AND

methodsRadiation treatment planning CT scans were coregistered with pretreatment [

resultsAnatomic lung dosimetric parameters (MLD) and functional lung dosimetric parameters (pMLD

conclusionsThe preliminary application of this framework revealed differences between anatomic and perfused lung dosimetry in this limited patient cohort. The addition of perfused lung parameters may help risk stratify patients for radiation pneumonitis, especially in treatment plans with high anatomic mean lung dose. Further investigations are warranted.

Indexed as

AgedAged, 80 and overFemaleHumansLung NeoplasmsMaleMiddle AgedRadiation PneumonitisRadiometryRadiotherapy DosageRadiotherapy Planning, Computer-AssistedReproducibility of ResultsRisk AssessmentSensitivity and SpecificitySingle Photon Emission Computed Tomography Computed TomographyTreatment OutcomeComputed tomographyRadiotherapySequelaeSPECTToxicity

Identifiers

PMID28255667
PMCPMC5406240

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.