Evidence map›Paper›PMID 28255581›Full record

ArticleJournal of neurology & neuromedicine2016

Feasibility study for remote assessment of cognitive function in multiple sclerosis.

Michaela F George, Calliope B Holingue, Farren B S Briggs, Xiaorong Shao, Kalliope H Bellesis, Rachel A Whitmer, Catherine Schaefer, Ralph Hb Benedict, Lisa F Barcellos

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of neurology & neuromedicine, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
0.7field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 20 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. The reliability and validity of the Turkish version of the Telemedicine Satisfaction and Usefulness Questionnaire (TSUQ) and Telemedicine Patient Questionnaire (TPQ) in individuals with multiple sclerosis.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2022
    Article
  5. Review
  6. Article
  7. Article
  8. Cognitive Assessment via Telephone: A Scoping Review of Instruments.Archives of clinical neuropsychology : the official journal of the National Academy of Neuropsychologists · 2020
    Article
  9. Review
  10. Article
  11. Article
  12. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 1 institution in 1 country.

Michaela F GeorgeDivision of Epidemiology, Genetic Epidemiology and Genomics Laboratory, School of Public Health, University of California, Berkeley, CA, USA.
Calliope B HolingueDivision of Epidemiology, Genetic Epidemiology and Genomics Laboratory, School of Public Health, University of California, Berkeley, CA, USA.
Farren B S BriggsDepartment of Epidemiology and Biostatistics, School of Medicine, Case Western Reserve University, Cleveland, OH, USA.
Xiaorong ShaoDivision of Epidemiology, Genetic Epidemiology and Genomics Laboratory, School of Public Health, University of California, Berkeley, CA, USA.
Kalliope H BellesisKaiser Permanente Division of Research, Oakland, CA, USA.
Rachel A WhitmerKaiser Permanente Division of Research, Oakland, CA, USA.
Catherine SchaeferKaiser Permanente Division of Research, Oakland, CA, USA.
Ralph Hb BenedictJacobs MS Center, SUNY Buffalo School of Medicine, Buffalo, NY, USA.
Lisa F BarcellosDivision of Epidemiology, Genetic Epidemiology and Genomics Laboratory, School of Public Health, University of California, Berkeley, CA, USA; Kaiser Permanente Division of Research, Oakland, CA, USA.
University of California, Berkeley · US

Funding

The Identification of Risk Factors for the Complex MS PhenotypeR01AI076544 · NIAID · UNIVERSITY OF CALIFORNIA BERKELEY · PI BARCELLOS, LISA F · 2008 to 2012
$3.6M
Novel Strategies to Identify GxE Contributions to MS PathogenesisR01ES017080 · NIEHS · UNIVERSITY OF CALIFORNIA BERKELEY · PI BARCELLOS, LISA F · 2011 to 2015
$3.0M
Genetic and non-genetic risk factors in MSR01NS049510 · NINDS · UNIVERSITY OF CALIFORNIA BERKELEY · PI BARCELLOS, LISA F · 2005 to 2009
$2.7M
NIAID NIH HHS R01 AI076544NIEHS NIH HHS R01 ES017080NINDS NIH HHS R01 NS049510
6 · The paper itself

Abstract

backgroundCognitive impairment is common in multiple sclerosis (MS), and affects employment and quality of life. Large studies are needed to identify risk factors for cognitive decline. Currently, a MS-validated remote assessment for cognitive function does not exist. Studies to determine feasibility of large remote cognitive function investigations in MS have not been published.

objectiveTo determine whether MS patients would participate in remote cognitive studies. We utilized the Modified Telephone Interview for Cognitive Status (TICS-M), a previously validated phone assessment for cognitive function in healthy elderly populations to detect mild cognitive impairment. We identified factors that influenced participation rates. We investigated the relationship between MS risk factors and TICS-M score in cases, and score differences between cases and control individuals.

methodsThe TICS-M was administered to MS cases and controls. Linear and logistic regression models were utilized.

results11.5% of eligible study participants did not participate in cognitive testing. MS cases, females and individuals with lower educational status were more likely to refuse (p<0.001). Cases who did complete testing did not differ in terms of perceived cognitive deficit compared to cases that did participate. More severe disease, smoking, and being male were associated with a lower TICS-M score among cases (p<0.001). The TICS-M score was significantly lower in cases compared to controls (p=0.007).

conclusionsOur results demonstrate convincingly that a remotely administered cognitive assessment is quite feasible for conducting large epidemiologic studies in MS, and lay the much needed foundation for future work that will utilize MS-validated cognitive measures.

Indexed as

Autoimmune diseaseCase control studiesCognitive impairmentHLA-DRB1Multiple sclerosisMultiple Sclerosis Severity ScorePDQTICS-M

Identifiers

PMID28255581
PMCPMC5330281
OpenAlexW2745419275

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.