Evidence map›Paper›PMID 28255560›Full record

ArticleJournal of immunology research2017

Humoral Responses to Rv1733c, Rv0081, Rv1735c, and Rv1737c DosR Regulon-Encoded Proteins of

Simon G Kimuda, Angela Nalwoga, Jonathan Levin, Kees L M C Franken, Tom H M Ottenhoff, Alison M Elliott, Stephen Cose, Irene Andia-Biraro

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of immunology research, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed, 1 pooled it
1.6field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 1 synthesis or guideline pooled it, 18 citations in OpenAlex.

  1. Pooled it
  2. Two-HitFrontiers in immunology · 2019
    Trial
  3. Article
  4. Article
  5. Review
  6. Maternal LatentFrontiers in immunology · 2020
    Observational
  7. Article
  8. Article
  9. Frontiers in microbiology · 2017
    Article
  10. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 4 institutions in 3 countries.

Simon G KimudaCollege of Health Sciences, Makerere University, P.O. Box 7072, Kampala, Uganda; Medical Research Council/UVRI Uganda Research Unit on AIDS, P.O. Box 49, Plot 51-59 Nakiwogo Road, Entebbe, Uganda.ORCID 0000-0001-6818-617X
Angela NalwogaMedical Research Council/UVRI Uganda Research Unit on AIDS, P.O. Box 49, Plot 51-59 Nakiwogo Road, Entebbe, Uganda; Department of Clinical Research, London School of Hygiene and Tropical Medicine, Keppel Street, London WC1E 7HT, UK.
Jonathan LevinMedical Research Council/UVRI Uganda Research Unit on AIDS, P.O. Box 49, Plot 51-59 Nakiwogo Road, Entebbe, Uganda.
Kees L M C FrankenDepartment of Immunohematology and Blood Transfusion and Department of Infectious Diseases, Leiden University Medical Centre, 2300 RC Leiden, Netherlands.ORCID 0000-0002-4747-6060
Tom H M OttenhoffDepartment of Immunohematology and Blood Transfusion and Department of Infectious Diseases, Leiden University Medical Centre, 2300 RC Leiden, Netherlands.
Alison M ElliottMedical Research Council/UVRI Uganda Research Unit on AIDS, P.O. Box 49, Plot 51-59 Nakiwogo Road, Entebbe, Uganda; Department of Clinical Research, London School of Hygiene and Tropical Medicine, Keppel Street, London WC1E 7HT, UK.
Stephen CoseCollege of Health Sciences, Makerere University, P.O. Box 7072, Kampala, Uganda; Medical Research Council/UVRI Uganda Research Unit on AIDS, P.O. Box 49, Plot 51-59 Nakiwogo Road, Entebbe, Uganda; Department of Clinical Research, London School of Hygiene and Tropical Medicine, Keppel Street, London WC1E 7HT, UK.
Irene Andia-BiraroCollege of Health Sciences, Makerere University, P.O. Box 7072, Kampala, Uganda; Medical Research Council/UVRI Uganda Research Unit on AIDS, P.O. Box 49, Plot 51-59 Nakiwogo Road, Entebbe, Uganda.
University of London · GBLeiden University · NLMakerere University · UGUganda Virus Research Institute · UG

Funding

Wellcome Trust 084344Wellcome Trust 107743
6 · The paper itself

Abstract

Latent tuberculosis infection (LTBI) is evidence of immunological control of tuberculosis. Dormancy survival regulator (DosR) regulon-encoded proteins may have a role in the maintenance of LTBI. T cell responses to Rv1733c, Rv0081, Rv1735c, and Rv1737c DosR regulon-encoded proteins were found to be most frequent among household contacts of TB cases from Uganda compared to other DosR proteins, but antibody responses were not described. We characterized antibody responses to these proteins in individuals from Uganda. Antibodies to Rv1733c, Rv0081, Rv1735c, and Rv1737c DosR regulon-encoded proteins were measured in 68 uninfected individuals, 62 with LTBI, and 107 with active pulmonary tuberculosis (APTB) cases. There were no differences in the concentrations of antibodies to Rv0081, Rv1735c, and Rv1737c DosR regulon-encoded proteins between individuals with LTBI and APTB and those who were uninfected. LTBI was associated with higher concentrations of antibodies to Rv1733c in female participants [adjusted geometric mean ratio: 1.812, 95% confidence interval (CI): 1.105 2.973, and

Indexed as

Immunity, HumoralRegulonAdolescentAdultAntibodies, BacterialAntigens, BacterialBacterial ProteinsDNA-Binding ProteinsFemaleHumansImmunoglobulin GLatent TuberculosisMaleMycobacterium tuberculosisProtein KinasesT-LymphocytesAntibodies, BacterialAntigens, BacterialBacterial ProteinsDNA-Binding ProteinsDosR protein, Mycobacterium tuberculosisImmunoglobulin GProtein KinasesRv1733c protein, Mycobacterium tuberculosis

Identifiers

PMID28255560
PMCPMC5309422
OpenAlexW2584943755

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.