Evidence map›Paper›PMID 28255558›Full record

ArticleBioMed research international2017

Buparvaquone Nanostructured Lipid Carrier: Development of an Affordable Delivery System for the Treatment of Leishmaniases.

Lis Marie Monteiro, Raimar Löbenberg, Paulo Cesar Cotrim, Gabriel Lima Barros de Araujo, Nádia Bou-Chacra

Open access · hybridAbstract read
In one paragraph

Article in BioMed research international, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
5.2field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 45 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Review
  5. Article
  6. Article
  7. Review
  8. Review
  9. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 2 countries.

Lis Marie MonteiroDepartment of Pharmacy, Faculty of Pharmaceutical Sciences, University of São Paulo, Professor Lineu Prestes Av 580, Cidade Universitária, 05508-000 São Paulo, SP, Brazil.ORCID 0000-0001-6409-0672
Raimar LöbenbergFaculty of Pharmacy and Pharmaceutical Sciences, University of Alberta, 8613 114th St NW, Edmonton, AB, Canada T6G 2H7.
Paulo Cesar CotrimSeroepidemiology, Cellular and Molecular Immunology Laboratory, Institute of Tropical Medicine, University of São Paulo, Dr. Enéas de Carvalho Aguiar 470, Jardim América, 05403-000 São Paulo, SP, Brazil.
Gabriel Lima Barros de AraujoDepartment of Pharmacy, Faculty of Pharmaceutical Sciences, University of São Paulo, Professor Lineu Prestes Av 580, Cidade Universitária, 05508-000 São Paulo, SP, Brazil.ORCID 0000-0001-7590-3587
Nádia Bou-ChacraDepartment of Pharmacy, Faculty of Pharmaceutical Sciences, University of São Paulo, Professor Lineu Prestes Av 580, Cidade Universitária, 05508-000 São Paulo, SP, Brazil.ORCID 0000-0002-5271-5468
Universidade de São Paulo · BRUniversity of Alberta · CA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Buparvaquone (BPQ), a veterinary drug, was formulated as nanostructured lipid carriers (NLC) for leishmaniases treatment. The formulation design addressed poor water solubility of BPQ and lack of human drug delivery system. The DSC/TG and microscopy methods were used for solid lipids screening. Softisan® 154 showed highest BPQ solubility in both methods. The BPQ solubility in liquid lipids using HPLC revealed Miglyol® 812 as the best option. Response surface methodology (RSM) was used to identify the optimal Softisan154 : Miglyol 812 ratios (7 : 10 to 2 : 1) and Kolliphor® P188 and Tween® 80 concentration (>3.0% w/w) aiming for

Indexed as

Drug Delivery SystemsAnalysis of VarianceCalorimetry, Differential ScanningChemistry, PharmaceuticalCrystallizationDrug CarriersHumansLeishmaniasisLipidsMicroscopyNanostructuresNaphthoquinonesSolubilityStatic ElectricitybuparvaquoneDrug CarriersLipidsNaphthoquinones

Identifiers

PMID28255558
PMCPMC5309432
OpenAlexW2584936590

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.