Evidence map›Paper›PMID 28255531›Full record

ArticleCurrent oral health reports2016

Progress in Bioengineered Whole Tooth Research: From Bench to Dental Patient Chair.

Elizabeth E Smith, Pamela C Yelick

Open access · greenAbstract read
In one paragraph

Article in Current oral health reports, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
1.8field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 17 citations in OpenAlex.

  1. Review
  2. Review
  3. Review
  4. Review
  5. Review
  6. Tooth Formation: Are the Hardest Tissues of Human Body Hard to Regenerate?International journal of molecular sciences · 2020
    Review
  7. Bioengineering Tooth Bud Constructs Using GelMA Hydrogel.Methods in molecular biology (Clifton, N.J.) · 2019
    Article
  8. Article
  9. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Elizabeth E SmithDepartment of Cell, Molecular, and Developmental Biology, Sackler School of Graduate Biomedical Sciences, Tufts University School Medicine, Department of Orthodontics, Tufts University School of Dental Medicine.
Pamela C YelickDirector, Division of Craniofacial and Molecular Genetics, Professor, Department of Orthodontics, Tufts University School of Dental Medicine, Department of Biomedical Engineering, Tufts University, Department of Cell, Molecular, and Developmental Biology, Sackler School of Graduate Biomedical Sciences Tufts University School of Medicine, 136 Harrison Avenue, M824, Boston MA 02111.
Tufts University · US

Funding

Dental Stem Cells and Tooth Tissue EngineeringR01DE016132 · NIDCR · TUFTS UNIVERSITY BOSTON · PI YELICK, PAMELA C · 2005 to 2014
$5.5M
Bioengineered Composite Alveolar Bone-Tooth Constructs for Tooth RegenerationR01DE026731 · NIDCR · TUFTS UNIVERSITY BOSTON · PI YELICK, PAMELA C · 2017 to 2021
$3.6M
Bioengineered 3D Tooth Constructs for Whole Tooth RegenerationF31DE026361 · NIDCR · TUFTS UNIVERSITY BOSTON · PI SMITH, ELIZABETH ERIN · 2016 to 2017
$76k
NIDCR NIH HHS F31 DE026361NIDCR NIH HHS R01 DE016132NIDCR NIH HHS R01 DE026731
6 · The paper itself

Abstract

Tooth loss is a significant health issue that affects the physiological and social aspects of everyday life. Missing teeth impair simple tasks of chewing and speaking, and can also contribute to reduced self-confidence. An emerging and exciting area of regenerative medicine based dental research focuses on the formation of bioengineered whole tooth replacement therapies that can provide both the function and sensory responsiveness of natural teeth. This area of research aims to enhance the quality of dental and oral health for those suffering from tooth loss. Current approaches use a combination of dental progenitor cells, scaffolds and growth factors to create biologically based replacement teeth to serve as improved alternatives to currently used artificial dental prosthetics. This article is an overview of current progress, challenges, and future clinical applications of bioengineered whole teeth.

Indexed as

AmeloblastCell DifferentiationDentinOdontoblastsOdontogenesisTooth Loss

Identifiers

PMID28255531
PMCPMC5328640
OpenAlexW2507342639

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.