ArticleOncoimmunology2016
The presence of CXCR4
Article in Oncoimmunology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
6 citing papers in PubMed, 11 citations in OpenAlex.
- Targeting of SIRPα as a potential therapy for Langerhans cell histiocytosis.Cancer science · 2023Article
- Notch-dependent cooperativity between myeloid lineages promotes Langerhans cell histiocytosis pathology.Science immunology · 2022Article
- Signaling pathways, microenvironment, and targeted treatments in Langerhans cell histiocytosis.Cell communication and signaling : CCS · 2022Review
- Does CD1a Expression Influence T Cell Function in Patients With Langerhans Cell Histiocytosis?Frontiers in immunology · 2021Article
- The coming of age of Langerhans cell histiocytosis.Nature immunology · 2020Article
- Altered Populations of Unconventional T Cell Lineages in Patients with Langerhans Cell Histiocytosis.Scientific reports · 2018Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 4 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeLangerhans Cell Histiocytosis (LCH) is a neoplastic disorder characterized by tissue accumulating CD1a EXPERIMENTAL
designCXCR4, CXCL12 and TNF protein expression was immunohistochemically analyzed in 70 LCH-affected biopsies. The presence of CXCR4
resultsCXCL12 was detected in 68/70 (97%) biopsies. CXCR4
conclusionsThis study provides the first evidence that CXCR4 is involved in the homing and retention of LCH-cells in CXCL12-expressing tissues and qualifies CXCR4 as a candidate prognostic marker for less favorable disease outcome.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.