Evidence map›Paper›PMID 28255515›Full record

ArticleJournal of AIDS & clinical research2016

Microarrays-Enabled Hypothesis Generation: The Suspect Role of FNBP-1 in Neuropsychiatric Pathogenesis Associated with HIV and/or HCV Infection.

A Katsounas, K R Wilting, R A Lempicki, J F Schlaak, G Gerken

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In one paragraph

Article in Journal of AIDS & clinical research, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact, top 89% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 0 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 3 countries.

A KatsounasDepartment of Gastroenterology and Hepatology, University Hospital Essen, Hufelandstrasse 55, 45147 Essen, Germany; Laboratory of Immunopathogenesis and Bioinformatics, Leidos Biomedical Research, Inc., National Cancer Institute at Frederick, Frederick, MD 21702, USA.
K R WiltingDepartment for Medical Microbiology and Infection Prevention, University Medical Center Groningen, Hanzeplein 1 (9713 GZ) Groningen, the Netherlands.
R A LempickiLaboratory of Immunopathogenesis and Bioinformatics, Leidos Biomedical Research, Inc., National Cancer Institute at Frederick, Frederick, MD 21702, USA.
J F SchlaakEvangelisches Klinikum Niederrhein gGmbH, Duisburg, Germany.
G GerkenDepartment of Gastroenterology and Hepatology, University Hospital Essen, Hufelandstrasse 55, 45147 Essen, Germany.
Leidos (United States) · USEssen University Hospital · DE

Funding

CCR NIH HHS HHSN261200800001CNCI NIH HHS HHSN261200800001E
6 · The paper itself

Abstract

objectiveThe spectrum of neuropsychiatric illness (NI) associated with the Human Immunodeficiency Virus (HIV) and/or the Hepatitis C Virus (HCV) is far reaching and significantly impacts the clinical presentation and outcome of infected persons; however, the etiological and pathophysiological background remains partially understood. The present work was aimed to investigate the potential significance of formin binding protein 1 (FNBP-1)-dependent pathways in NI-pathogenesis by elaborating on previous microarray-based research in HIV and/or HCV-infected patients receiving interferon-α (IFN-α) immunotherapy via a rigorous data mining procedure.

methodsUsing microarray data of peripheral whole blood (PB) samples obtained from HCV mono-infected persons (n=25, Affymetrix

resultsAmong 28 gene expression profiles (HIV/HCV: N=9 vs. HCV: N=19) selected by applying different thresholds (a Mean Fold Difference value (MFD) in gene expression of ≥ 0.38 (log

conclusionOur current findings are strongly arguing for intensifying research into the FNBP-1-related mechanisms that may be conferring risk for or resistance to HIV- and/or HCV-related NI.

Indexed as

FNBP-1HCVHIVMicroarrayNeuropsychiatric disease

Identifiers

PMID28255515
PMCPMC5330367
OpenAlexW2571235041

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.