ArticleTherapeutic advances in drug safety2017
Adverse drug reactions due to cancer chemotherapy in a tertiary care teaching hospital.
Article in Therapeutic advances in drug safety, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 1 of them a synthesis that pooled it.
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Who cites it
22 citing papers in PubMed, 1 synthesis or guideline pooled it, 75 citations in OpenAlex.
- Exposure to Antineoplastic Drugs in Occupational Settings: A Systematic Review of Biological Monitoring Data.International journal of environmental research and public health · 2022Pooled it
- Inspiratory muscle training in addition to conventional physical rehabilitation in hospitalized patients undergoing hematopoietic stem cell transplantation: a randomized controlled trial.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2022Trial
- Safety and feasibility of inspiratory muscle training for hospitalized patients undergoing hematopoietic stem cell transplantation: a randomized controlled study.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2020Trial
- Evaluation of the efficacy of duloxetine and venlafaxine in chemotherapy-induced neuropathy in cancer patients: a double-blind multicenter randomized clinical trial.Annals of medicine and surgery (2012) · 2026Article
- Observational
- Chemotherapy-Induced Toxicities in Pediatric Cancer Patients: A Cross-Sectional Survey Using a Child- and Caregiver-Reported Outcome Tool in Tanzania.Drug, healthcare and patient safety · 2026Article
- Toxicity and antiproliferative activity assessment of a novel compound Zr I isolated from Zingiber roseum Rosc.Naunyn-Schmiedeberg's archives of pharmacology · 2026Article
- Systematic review and meta-analysis of chemotherapy-induced adverse drug reactions among children with cancer in Africa.Infectious agents and cancer · 2025Review
- Myalgia and Rigidity as Adverse Effects of Trametinib Therapy.The journal of pediatric pharmacology and therapeutics : JPPT : the official journal of PPAG · 2025Article
- Observational
- Adverse Drug Reactions and Predictors of Medication Adherence in Patients with Prostate Cancer.The Canadian journal of hospital pharmacy · 2024Article
- Review
- Development of evidence-based indicators for the detection of drug-related problems among ovarian cancer patients.Frontiers in pharmacology · 2023Article
- Quality of life and wellbeing among breast cancer patients in Lahore, Pakistan.Frontiers in oncology · 2023Article
- Evaluation of Factors Associated with Adverse Drug Events in South Korea Using a Population-Based Database.Journal of clinical medicine · 2022Article
- Chemical risk in hospital settings: Overview on monitoring strategies and international regulatory aspects.Journal of public health research · 2021Article
- Clinical application of comfort nursing in elderly patients with advanced lung cancer.American journal of translational research · 2021Article
- Frequency, nature, severity and preventability of adverse drug reactions arising from cancer chemotherapy in a teaching hospital.Journal of family medicine and primary care · 2020Article
- Serious adverse effects occurring after chemotherapy: A general cancer registry-based incidence survey.British journal of clinical pharmacology · 2020Article
- Chemotherapy-Related Adverse Drug Reaction and Associated Factors Among Hospitalized Paediatric Cancer Patients at Hospitals in North-West Ethiopia.Drug, healthcare and patient safety · 2020Article
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundAn adverse drug reaction (ADR) is defined by World Health Organization (WHO) as 'Any response to a drug which is noxious, unintended and occurs at doses used in man for prophylaxis, diagnosis or therapy'. ADRs associated with cancer chemotherapy warrant analysis on their severity and preventability. The outcome would create awareness among health care providers and prevent their recurrence. We have performed a hospital-based prospective observational study designed to analyze the pattern of ADRs to chemotherapeutic agents in cancer patients of a tertiary care hospital.
methodsA total of 119 cancer patients were monitored for suspected ADRs during the course of chemotherapy from November 2014 to December 2015. Clinical events were recorded and analyzed with regard to the demographics and drug details of the patients.
resultsA total of 106 ADRs were recorded from 119 cases. The ADRs commonly encountered included constipation, nausea, vomiting, alopecia and hematological changes. Cisplatin, cyclophosphamide, paclitaxel and 5-FU were used for the treatment of commonly found cancers in this region affecting the lungs, esophagus and lymphomas. Naranjo's causality assessment showed 86.7% possible (score 4) and 13.2% probable (score 5-6). Severity of adverse reactions showed 77.4% mild, 18.9% moderate and 3.8% severe. A total of 45.3% of ADRs were preventable reactions such as nausea, vomiting and constipation.
conclusionsThis study highlights the role of active monitoring as an important tool for early detection, assessment and timely management of ADRs in patients undergoing cancer chemotherapy. The observed ADRs were preventable although ADRs such as hiccough, anemia, neutropenia and alopecia were not preventable.
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