Evidence map›Paper›PMID 28255366›Full record

ArticleTheranostics2017

Liposomal Nanoparticles Carrying anti-IL6R Antibody to the Tumour Microenvironment Inhibit Metastasis in Two Molecular Subtypes of Breast Cancer Mouse Models.

Chunlei Guo, Yanan Chen, Wenjuan Gao, Antao Chang, Yujie Ye, Wenzhi Shen, Yunping Luo, Shengyong Yang, Peiqing Sun, Rong Xiang and 1 more

Open access · goldAbstract read
In one paragraph

Article in Theranostics, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
29citing papers in PubMed, 1 pooled it
2.9field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

29 citing papers in PubMed, 1 synthesis or guideline pooled it, 71 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 4 institutions in 2 countries.

Chunlei GuoSchool of Medicine, Nankai University, 94 Weijin Road, Tianjin 300071, China.
Yanan ChenSchool of Medicine, Nankai University, 94 Weijin Road, Tianjin 300071, China.
Wenjuan GaoSchool of Medicine, Nankai University, 94 Weijin Road, Tianjin 300071, China.
Antao ChangSchool of Medicine, Nankai University, 94 Weijin Road, Tianjin 300071, China.
Yujie YeSchool of Medicine, Nankai University, 94 Weijin Road, Tianjin 300071, China.
Wenzhi ShenSchool of Medicine, Nankai University, 94 Weijin Road, Tianjin 300071, China.
Yunping LuoDepartment of Immunology, Institute of Basic Medical Science, Peking Union Medical College, Beijing 100730, China.
Shengyong YangState Key Laboratory of Biotherapy and Cancer Center, Sichuan University, Chengdu 610041, China.
Peiqing SunDepartment of Cancer Biology, Wake Forest University School of Medicine, Winston-Salem, NC 27157, USA.
Rong XiangSchool of Medicine, Nankai University, 94 Weijin Road, Tianjin 300071, China;; Tianjin Key Laboratory of Tumour Microenvironment and Neurovascular Regulation, Tianjin 300071, China.; Collaborative Innovation Center for Biotherapy, Nankai University, 94 Weijin Road, Tianjin 300071, China.
Na LiSchool of Medicine, Nankai University, 94 Weijin Road, Tianjin 300071, China;; Tianjin Key Laboratory of Tumour Microenvironment and Neurovascular Regulation, Tianjin 300071, China.; Collaborative Innovation Center for Biotherapy, Nankai University, 94 Weijin Road, Tianjin 300071, China.
Nankai University · CNChinese Academy of Medical Sciences & Peking Union Medical College · CNSichuan University · CNWake Forest University · US

Funding

Tip60 in p38 and PRAK Mediated Oncogene-Induced Senescence and Tumor SuppressionR01CA131231 · NCI · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI SUN, PEIQING · 2009 to 2018
$3.5M
The role of microRNA in oncogene-induced senescence and cancer developmentR01CA172115 · NCI · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI SUN, PEIQING · 2014 to 2018
$1.8M
NCI NIH HHS R01 CA131231NCI NIH HHS R01 CA172115
6 · The paper itself

Abstract

Tumour microenvironment (TME) contributes significantly towards potentiating the stemness and metastasis properties of cancer cells. IL6-Stat3 is one of the important cell signaling pathways in mediating the communication between tumour and immune cells. Here, we have systematically developed a novel anti-CD44 antibody-mediated liposomal nanoparticle delivery system loaded with anti-IL6R antibody, which could specifically target the TME of CD44

Indexed as

AnimalsAntibodiesBreast NeoplasmsDisease Models, AnimalHyaluronan ReceptorsLiposomesLungLung NeoplasmsMiceMice, Inbred BALB CNanoparticlesNeoplasm MetastasisReceptors, Interleukin-6Treatment OutcomeTumor MicroenvironmentAntibodiesCd44 protein, mouseHyaluronan ReceptorsLiposomesReceptors, Interleukin-6anti-IL6R antibodyliposomal nanoparticlesmetastasismetastatic niche.tumour microenvironment

Identifiers

PMID28255366
PMCPMC5327649
OpenAlexW2589368196

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.