Evidence map›Paper›PMID 28255362›Full record

ArticleTheranostics2017

HER Family Receptors are Important Theranostic Biomarkers for Cervical Cancer: Blocking Glucose Metabolism Enhances the Therapeutic Effect of HER Inhibitors.

Olga Martinho, Renato Silva-Oliveira, Fernanda P Cury, Ana Martins Barbosa, Sara Granja, Adriane Feijó Evangelista, Fábio Marques, Vera Miranda-Gonçalves, Diana Cardoso-Carneiro, Flávia E de Paula and 6 more

Registry-linked trialOpen access · goldAbstract read
In one paragraph

Article in Theranostics, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06558682 (Disitamab Vedotin Combined With Cisplatin for Neoadjuvant Therapy in Locally Advanced Cervical Cancer), which is not on this map. Cited by 27 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
27citing papers in PubMed, 1 pooled it
2.1field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06558682 narecruitingnot on this mapstarted 2024, after this paper: background citation

Disitamab Vedotin Combined With Cisplatin for Neoadjuvant Therapy in Locally Advanced Cervical Cancer: a Prospective, Single-arm Clinical Trial

TypeinterventionalSponsorQilu Hospital of Shandong UniversityRan2024 to 2026Enrolled48ConditionsUterine Cervical NeoplasmsArmsDisitamab Vedotin and Cisplatin
3 · Its place in the literature

Who cites it

27 citing papers in PubMed, 1 synthesis or guideline pooled it, 46 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Article
  4. Article
  5. Article
  6. Article
  7. Review
  8. Article
  9. Article
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  12. Article
  13. Review
  14. IL-17A and IL-17F orchestrate macrophages to promote lung cancer.Cellular oncology (Dordrecht, Netherlands) · 2020
    Article
  15. Article
  16. Review
  17. Article
  18. Molecules (Basel, Switzerland) · 2019
    Article
  19. Article
  20. Regulation of Cellular Metabolism by High-Risk Human Papillomaviruses.International journal of molecular sciences · 2018
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 3 institutions in 2 countries.

Olga MartinhoLife and Health Sciences Research Institute (ICVS), School of Medicine, University of Minho, Braga, Portugal;; ICVS/3B's - PT Government Associate Laboratory, Braga/Guimarães, Portugal;; Molecular Oncology Research Center (CPOM), Barretos Cancer Hospital, Barretos, São Paulo, Brazil.
Renato Silva-OliveiraMolecular Oncology Research Center (CPOM), Barretos Cancer Hospital, Barretos, São Paulo, Brazil.
Fernanda P CuryMolecular Oncology Research Center (CPOM), Barretos Cancer Hospital, Barretos, São Paulo, Brazil.
Ana Martins BarbosaLife and Health Sciences Research Institute (ICVS), School of Medicine, University of Minho, Braga, Portugal;; ICVS/3B's - PT Government Associate Laboratory, Braga/Guimarães, Portugal.
Sara GranjaLife and Health Sciences Research Institute (ICVS), School of Medicine, University of Minho, Braga, Portugal;; ICVS/3B's - PT Government Associate Laboratory, Braga/Guimarães, Portugal.
Adriane Feijó EvangelistaMolecular Oncology Research Center (CPOM), Barretos Cancer Hospital, Barretos, São Paulo, Brazil.
Fábio MarquesDepartment of Pathology of the School of Medicine of the Federal University of Goiás, Brazil.
Vera Miranda-GonçalvesLife and Health Sciences Research Institute (ICVS), School of Medicine, University of Minho, Braga, Portugal;; ICVS/3B's - PT Government Associate Laboratory, Braga/Guimarães, Portugal.
Diana Cardoso-CarneiroLife and Health Sciences Research Institute (ICVS), School of Medicine, University of Minho, Braga, Portugal;; ICVS/3B's - PT Government Associate Laboratory, Braga/Guimarães, Portugal.
Flávia E de PaulaMolecular Oncology Research Center (CPOM), Barretos Cancer Hospital, Barretos, São Paulo, Brazil.
Maicon ZanonMolecular Oncology Research Center (CPOM), Barretos Cancer Hospital, Barretos, São Paulo, Brazil.
Cristovam Scapulatempo-NetoMolecular Oncology Research Center (CPOM), Barretos Cancer Hospital, Barretos, São Paulo, Brazil.
Marise A R MoreiraDepartment of Pathology of the School of Medicine of the Federal University of Goiás, Brazil.
Fátima BaltazarLife and Health Sciences Research Institute (ICVS), School of Medicine, University of Minho, Braga, Portugal;; ICVS/3B's - PT Government Associate Laboratory, Braga/Guimarães, Portugal.
Adhemar Longatto-FilhoLife and Health Sciences Research Institute (ICVS), School of Medicine, University of Minho, Braga, Portugal;; ICVS/3B's - PT Government Associate Laboratory, Braga/Guimarães, Portugal;; Molecular Oncology Research Center (CPOM), Barretos Cancer Hospital, Barretos, São Paulo, Brazil;; Laboratory of Medical Investigation (LIM) 14, Faculty of Medicine, São Paulo State University, Brazil.
Rui Manuel ReisLife and Health Sciences Research Institute (ICVS), School of Medicine, University of Minho, Braga, Portugal;; ICVS/3B's - PT Government Associate Laboratory, Braga/Guimarães, Portugal;; Molecular Oncology Research Center (CPOM), Barretos Cancer Hospital, Barretos, São Paulo, Brazil.
University of Minho · PTHospital de Câncer de Barretos · BRUniversidade Federal de Goiás · BR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Persistent HPV infection alone is not sufficient for cervical cancer development, which requires additional molecular alterations for tumor progression and metastasis ultimately leading to a lethal disease. In this study, we performed a comprehensive analysis of HER family receptor alterations in cervical adenocarcinoma. We detected overexpression of HER protein, mainly HER2, which was an independent prognostic marker for these patients. By using

Indexed as

AcrylamidesAdenocarcinomaAntimetabolitesAntineoplastic AgentsBiomarkers, TumorDiagnostic Tests, RoutineDrug Resistance, NeoplasmErbB ReceptorsFemaleGlucoseHumansLapatinibQuinazolinesTheranostic NanomedicineTherapeutic UsesUterine Cervical NeoplasmsAcrylamidesAntimetabolitesAntineoplastic AgentsAST 1306Biomarkers, TumorErbB ReceptorsGlucoseLapatinibQuinazolinesTherapeutic Usescervical cancerEGFRErbBHER2prognosistargeted therapy.

Identifiers

PMID28255362
PMCPMC5327645
OpenAlexW2573550138

What OpenQuestion holds

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Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.