Evidence map›Paper›PMID 28255344›Full record

ArticleTheranostics2017

Functional Genomic mRNA Profiling of Colorectal Adenomas: Identification and

Elmire Hartmans, Veronique Orian-Rousseau, Alexandra Matzke-Ogi, Arend Karrenbeld, Derk Jan A de Groot, Steven de Jong, Gooitzen M van Dam, Rudolf S N Fehrmann, Wouter B Nagengast

Open access · goldAbstract readValidation Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Theranostics, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
1.1field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 12 citations in OpenAlex.

  1. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 2 countries.

Elmire HartmansDepartment of Gastroenterology and Hepatology, University of Groningen, University Medical Centre Groningen, Groningen, the Netherlands.
Veronique Orian-RousseauInstitute of Toxicology and Genetics, Karlsruhe Institute of Technology, Karlsruhe, Germany.
Alexandra Matzke-OgiAmcure GmbH, Eggenstein-Leopolshafen, Germany.
Arend KarrenbeldDepartment of Pathology, University of Groningen, University Medical Centre Groningen, Groningen, the Netherlands.
Derk Jan A de GrootDepartment of Medical Oncology, University of Groningen, University Medical Centre Groningen, Groningen, the Netherlands.
Steven de JongDepartment of Medical Oncology, University of Groningen, University Medical Centre Groningen, Groningen, the Netherlands.
Gooitzen M van DamDepartment of Surgery, Nuclear Medicine and Molecular Imaging and Intensive Care, University of Groningen, University Medical Centre Groningen, Groningen, the Netherlands.
Rudolf S N FehrmannDepartment of Medical Oncology, University of Groningen, University Medical Centre Groningen, Groningen, the Netherlands.
Wouter B NagengastDepartment of Gastroenterology and Hepatology, University of Groningen, University Medical Centre Groningen, Groningen, the Netherlands.
University of Groningen · NLUniversity Medical Center Groningen · NLKarlsruhe Institute of Technology · DEKerntechnische Entsorgung Karlsruhe (Germany) · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Colorectal cancer (CRC) is the third leading cause of cancer-related deaths worldwide. High adenoma miss rates, especially seen in high-risk patients, demand for better endoscopic detection. By fluorescently 'highlighting' specific molecular characteristics, endoscopic molecular imaging has great potential to fulfill this need. To implement this technique effectively, target proteins that distinguish adenomas from normal tissue must be identified. In this study we applied

Indexed as

AdenomaAnimalsColonoscopyColorectal NeoplasmsDiagnostic Tests, RoutineGene Expression ProfilingHumansHyaluronan ReceptorsImmunohistochemistryMiceMolecular ImagingRNA, MessengerCD44 protein, humanCD44v6 antigenHyaluronan ReceptorsRNA, MessengerCancer GeneticsCD44 / CD44v6.Colorectal adenomasFunctional GenomicsMolecular Targeted Imaging

Identifiers

PMID28255344
PMCPMC5327362
OpenAlexW2574463160

What OpenQuestion holds

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LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.