Evidence map›Paper›PMID 28255342›Full record

ArticleTheranostics2017

Dual-targeted and pH-sensitive Doxorubicin Prodrug-Microbubble Complex with Ultrasound for Tumor Treatment.

Wanxian Luo, Ge Wen, Li Yang, Jiao Tang, Jianguo Wang, Jihui Wang, Shiyu Zhang, Li Zhang, Fei Ma, Liling Xiao and 2 more

Open access · goldAbstract read
In one paragraph

Article in Theranostics, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.

0numbers the graph read from it
0cells of the map it votes in
27citing papers in PubMed
6.0field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

27 citing papers in PubMed, 89 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Review
  5. Article
  6. Article
  7. Article
  8. Review
  9. Review
  10. Article
  11. Review
  12. Review
  13. Article
  14. Article
  15. Review
  16. Article
  17. Article
  18. Article
  19. Hydrogen Gas in Cancer Treatment.Frontiers in oncology · 2019
    Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 2 institutions in 1 country.

Wanxian LuoDepartment of Medicine Ultrasonics, Nanfang Hospital, Southern Medical University, Guangzhou 510515, China;; Guangdong Provincial Key laboratory of cancer immunotherapy research, Cancer Research Institute, School of Basic Medical Science, Southern Medical University, Guangzhou 510515, China.
Ge WenImaging center, Nanfang Hospital, Southern Medical University, Guangzhou 510515, China.
Li YangDepartment of Pharmacy, Nanfang Hospital, Southern Medical University, Guangzhou 510515, China.
Jiao TangGuangdong Provincial Key laboratory of cancer immunotherapy research, Cancer Research Institute, School of Basic Medical Science, Southern Medical University, Guangzhou 510515, China.
Jianguo WangGuangdong Provincial Key laboratory of cancer immunotherapy research, Cancer Research Institute, School of Basic Medical Science, Southern Medical University, Guangzhou 510515, China.
Jihui WangGuangdong Provincial Key laboratory of cancer immunotherapy research, Cancer Research Institute, School of Basic Medical Science, Southern Medical University, Guangzhou 510515, China.
Shiyu ZhangDepartment of Medicine Ultrasonics, Nanfang Hospital, Southern Medical University, Guangzhou 510515, China.
Li ZhangDepartment of Medicine Ultrasonics, Nanfang Hospital, Southern Medical University, Guangzhou 510515, China.
Fei MaDepartment of Medicine Ultrasonics, Nanfang Hospital, Southern Medical University, Guangzhou 510515, China.
Liling XiaoDepartment of Medicine Ultrasonics, Nanfang Hospital, Southern Medical University, Guangzhou 510515, China.
Ying WangGuangdong Provincial Key laboratory of cancer immunotherapy research, Cancer Research Institute, School of Basic Medical Science, Southern Medical University, Guangzhou 510515, China.
Yingjia LiDepartment of Medicine Ultrasonics, Nanfang Hospital, Southern Medical University, Guangzhou 510515, China.
Southern Medical University · CNNanfang Hospital · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

In this study, we investigated the potential of a dual-targeted pH-sensitive doxorubicin prodrug-microbubble complex (DPMC) in ultrasound (US)-assisted antitumor therapy. The doxorubicin prodrug (DP) consists of a succinylated-heparin carrier conjugated with doxorubicin (DOX)

Indexed as

MicrobubblesAnimalsAntibiotics, AntineoplasticBreast NeoplasmsCell SurvivalDisease Models, AnimalDoxorubicinDrug CarriersEndocytosisEndothelial CellsHeterograftsHumansHydrogen-Ion ConcentrationMCF-7 CellsMiceMolecular Targeted TherapyAntibiotics, AntineoplasticDoxorubicinDrug CarriersProdrugsDoxorubicin prodrugDual-targetedMicrobubble complexpH-sensitiveUltrasound.

Identifiers

PMID28255342
PMCPMC5327360
OpenAlexW2575440227

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.