ArticleOncoTargets and therapy2017
Prognostic significance of tumor budding and single cell invasion in gastric adenocarcinoma.
Article in OncoTargets and therapy, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed, 36 citations in OpenAlex.
- Tumor Budding in Gastric Carcinoma: Beyond Counting Cells at the Invasive Front-A Review of Current Evidence and Biological Perspectives.International journal of molecular sciences · 2026Review
- Evaluating the diagnostic accuracy of dynamic CT transmural sign for T staging of gastric cancer compared to conventional CT criteria.BMC medical imaging · 2025Article
- Tumor budding in gastric adenocarcinoma: prognostic value and association with clinicopathological markers.Arquivos brasileiros de cirurgia digestiva : ABCD = Brazilian archives of digestive surgery · 2025Article
- Prognostic significance of tumor budding, desmoplastic reaction, and lymphocytic infiltration in patients with gastric adenocarcinoma.World journal of gastrointestinal pathophysiology · 2024Article
- The prognostic role of single cell invasion and nuclear diameter in early oral tongue squamous cell carcinoma.BMC cancer · 2024Article
- Prognostic Significance of Tumour Budding and Desmoplastic Reaction in Intestinal-Type Gastric Adenocarcinoma.International journal of surgical pathology · 2023Article
- Tumor budding as an indicator for lymph node metastasis and prognosis of early gastric cancer.Journal of cancer research and clinical oncology · 2023Article
- Tumor budding in gastric cancer.World journal of gastrointestinal surgery · 2023Review
- Prognostic Ability of Tumor Budding Outperforms Poorly Differentiated Clusters in Gastric Cancer.Cancers · 2022Article
- Article
- Is there still a place for conventional histopathology in the age of molecular medicine? Laurén classification, inflammatory infiltration and other current topics in gastric cancer diagnosis and prognosis.Histology and histopathology · 2021Review
- Joint Tumor Bud-MMP/TIMP Count at the Invasive Front Improves the Prognostic Evaluation of Invasive Breast Carcinoma.Biomedicines · 2021Article
- Tumour budding in solid cancers.Nature reviews. Clinical oncology · 2021Review
- Elevated ZBTB7A expression in the tumor invasive front correlates with more tumor budding formation in gastric adenocarcinoma.Journal of cancer research and clinical oncology · 2021Article
- Tumour budding and its clinical implications in gastrointestinal cancers.British journal of cancer · 2020Review
- Three-dimensional analysis of extrahepatic cholangiocarcinoma and tumor budding.The Journal of pathology · 2020Article
- Tumor Budding Detection System in Whole Slide Pathology Images.Journal of medical systems · 2019Article
- Prognostic and pathological impact of tumor budding in gastric cancer: A systematic review and meta-analysis.World journal of gastrointestinal oncology · 2019Article
- Tumor budding for predicting prognosis of resected rectum cancer after neoadjuvant treatment.World journal of surgical oncology · 2019Article
- Prognostic role of tumor budding in breast cancer.World journal of experimental medicine · 2018Article
Corrections and comments
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Authors and funding
8 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeGastric carcinoma (GC) is a highly aggressive cancer and one of the leading causes of cancer-related deaths worldwide. Histopathological evaluation pertaining to invasiveness is likely to provide additional information in relation to patient outcome. In this study, we aimed to evaluate the prognostic significance of tumor budding and single cell invasion in gastric adenocarcinoma. MATERIALS AND
methodsHematoxylin and eosin-stained slides generated from 296 gastric adenocarcinoma patients with full clinical and pathological and follow-up information were systematically reviewed. The patients were grouped on the basis of tumor budding, single cell invasion, large cell invasion, mitotic count, and fibrosis. The association between histopathological parameters, different classification systems, and overall survival (OS) was statistically analyzed.
resultsAmong the 296 cases that were analyzed, high-grade tumor budding was observed in 49.0% (145) of them. Single cell invasion and large cell invasion were observed in 62.8% (186) and 16.9% (50) of the cases, respectively. Following univariate analysis, patients with high-grade tumor budding had shorter OS than those with low-grade tumor budding (hazard ratio [HR]: 2.260,
conclusionTumor budding and single cell invasion in gastric adenocarcinoma are associated with an unfavorable prognosis.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.