Evidence map›Paper›PMID 28255077›Full record

ArticleJournal of the American Heart Association2017

Echocardiographic Screening for Rheumatic Heart Disease in Indigenous Australian Children: A Cost-Utility Analysis.

Kathryn Roberts, Jeffrey Cannon, David Atkinson, Alex Brown, Graeme Maguire, Bo Remenyi, Gavin Wheaton, Elizabeth Geelhoed, Jonathan R Carapetis

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of the American Heart Association, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed, 1 pooled it
5.0field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed, 1 synthesis or guideline pooled it, 47 citations in OpenAlex.

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  11. Global epidemiology of valvular heart disease.Nature reviews. Cardiology · 2021
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

9 authors at 7 institutions in 1 country.

Kathryn RobertsMenzies School of Health Research, Royal Darwin Hospital Campus, Darwin, Northern Territory, Australia.
Jeffrey CannonTelethon Kids Institute, The University of Western Australia, Subiaco, Western Australia, Australia jeffrey.cannon@telethonkids.org.au.
David AtkinsonRural Clinical School of Western Australia, University of Western Australia, Broome, Western Australia, Australia.
Alex BrownSouth Australian Health and Medical Research Institute, Adelaide, South Australia, Australia.
Graeme MaguireBaker IDI Heart and Diabetes Institute, Melbourne, Victoria, Australia.
Bo RemenyiMenzies School of Health Research, Royal Darwin Hospital Campus, Darwin, Northern Territory, Australia.
Gavin WheatonWomen's and Children's Hospital, Adelaide, South Australia, Australia.
Elizabeth GeelhoedTelethon Kids Institute, The University of Western Australia, Subiaco, Western Australia, Australia.
Jonathan R CarapetisTelethon Kids Institute, The University of Western Australia, Subiaco, Western Australia, Australia.
The Kids Research Institute Australia · AUBaker Heart and Diabetes Institute · AUEnvirons Kimberley · AUMenzies School of Health Research · AURoyal Darwin Hospital · AUSouth Australian Health and Medical Research Institute · AUWomen's and Children's Hospital · AU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundRheumatic heart disease (RHD) remains a leading cause of cardiovascular morbidity and mortality in children and young adults in disadvantaged populations. The emergence of echocardiographic screening provides the opportunity for early disease detection and intervention. Using our own multistate model of RHD progression derived from Australian RHD register data, we performed a cost-utility analysis of echocardiographic screening in indigenous Australian children, with the dual aims of informing policy decisions in Australia and providing a model that could be adapted in other countries. METHODS AND

resultsWe simulated the outcomes of 2 screening strategies, assuming that RHD could be detected 1, 2, or 3 years earlier by screening. Outcomes included reductions in heart failure, surgery, mortality, disability-adjusted life-years, and corresponding costs. Only a strategy of screening all indigenous 5- to 12-year-olds in half of their communities in alternate years was found to be cost-effective (incremental cost-effectiveness ratio less than AU$50 000 per disability-adjusted life-year averted), assuming that RHD can be detected at least 2 years earlier by screening; however, this result was sensitive to a number of assumptions. Additional modeling of improved adherence to secondary prophylaxis alone resulted in dramatic reductions in heart failure, surgery, and death; these outcomes improved even further when combined with screening.

conclusionsEchocardiographic screening for RHD is cost-effective in our context, assuming that RHD can be detected ≥2 years earlier by screening. Our model can be adapted to any other setting but will require local data or acceptable assumptions for model parameters.

Indexed as

AdolescentAustraliaCardiac Surgical ProceduresChildChild, PreschoolCost-Benefit AnalysisDisease ProgressionEchocardiographyFemaleHeart FailureHumansMaleMass ScreeningMortalityNorthern TerritoryQuality-Adjusted Life Yearscost‐effectivenessechocardiographypediatricsrheumatic heart diseasescreening

Identifiers

PMID28255077
PMCPMC5524001
OpenAlexW2594201067

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.