ArticleJournal of the American Heart Association2017
Rheumatic Heart Disease Severity, Progression and Outcomes: A Multi-State Model.
Article in Journal of the American Heart Association, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.
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Who cites it
35 citing papers in PubMed.
- An echocardiographic appreciation of rheumatic heart disease: phenotypic variability of valvular involvement and its prognostic implications.Lancet regional health. Americas · 2026Review
- Artificial intelligence-enhanced electrocardiogram for the detection of rheumatic heart disease.European heart journal. Digital health · 2026Article
- Application of the New 2023 World Heart Federation Criteria to Rheumatic Heart Disease in the Setting of First Episode of Acute Rheumatic Fever: Predictors for Resolution.Pediatric cardiology · 2026Article
- Article
- Connections Reduce Rheumatic Heart Disease-Related Mortality in Western Australia: A Mixed Methods Study.The Australian journal of rural health · 2025Article
- Application of the 2023 World Heart Federation guidelines for the echocardiographic diagnosis of rheumatic heart disease.Australasian journal of ultrasound in medicine · 2025Article
- The Impact of Acute Rheumatic Fever Diagnosis on Rheumatic Heart Disease Severity.Global heart · 2025Article
- Rheumatic Fever Unveiled in a 13-Year-Old Misdiagnosed With Appendicitis.JACC. Case reports · 2024Article
- Article
- Health-related quality of life and healthcare consultations among adult patients before and after diagnosis with rheumatic heart disease in Namibia.BMC cardiovascular disorders · 2023Article
- Surgery for rheumatic heart disease in the Northern Territory, Australia, 1997-2016: what have we gained?BMJ global health · 2023Article
- Exposure to Air Pollution during Pre-Hypertension and Subsequent Hypertension, Cardiovascular Disease, and Death: A Trajectory Analysis of the UK Biobank Cohort.Environmental health perspectives · 2023Article
- Survival of Rheumatic Heart Disease in Indonesian Children.Global heart · 2022Article
- Machine learning methods for predicting major types of rheumatic heart diseases in children of Southern Punjab, Pakistan.Frontiers in cardiovascular medicine · 2022Article
- Long-term outcomes following rheumatic heart disease diagnosis in Australia.European heart journal open · 2021Article
- Rheumatic Fever and Rheumatic Heart Disease-Related Knowledge, Attitude, and Practice in Saudi Arabia.Cureus · 2021Article
- Rheumatic heart disease in The Gambia: clinical and valvular aspects at presentation and evolution under penicillin prophylaxis.BMC cardiovascular disorders · 2021Article
- A case report: cardiac dysphagia-a ghost of the past?European heart journal. Case reports · 2021Article
- Multi-state model for predicting ocular progression in acute Stevens-Johnson syndrome/toxic epidermal necrolysis.PloS one · 2021Article
- Improvement of Rheumatic Valvular Heart Disease in Patients Undergoing Prolonged Antibiotic Prophylaxis.Frontiers in cardiovascular medicine · 2021Article
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4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundRheumatic heart disease (RHD) remains a disease of international importance, yet little has been published about disease progression in a contemporary patient cohort. Multi-state models provide a well-established method of estimating rates of transition between disease states, and can be used to evaluate the cost-effectiveness of potential interventions. We aimed to create a multi-state model for RHD progression using serial clinical data from a cohort of Australian patients. METHODS AND
resultsThe Northern Territory RHD register was used to identify all Indigenous residents diagnosed with RHD between the ages of 5 and 24 years in the time period 1999-2012. Disease severity over time, surgeries, and deaths were evaluated for 591 patients. Of 96 (16.2%) patients with severe RHD at diagnosis, 50% had proceeded to valve surgery by 2 years, and 10% were dead within 6 years. Of those diagnosed with moderate RHD, there was a similar chance of disease regression or progression over time. Patients with mild RHD at diagnosis were the most stable, with 64% remaining mild after 10 years; however, 11.4% progressed to severe RHD and half of these required surgery.
conclusionsThe prognosis of young Indigenous Australians diagnosed with severe RHD is bleak; interventions must focus on earlier detection and treatment if the observed natural history is to be improved. This multi-state model can be used to predict the effect of different interventions on disease progression and the associated costs.
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