Evidence map›Paper›PMID 28254773›Full record

ArticleAmerican journal of physiology. Gastrointestinal and liver physiology2017

Pharyngeal peristaltic pressure variability, operational range, and functional reserve.

Mark K Kern, Gokulakrishnan Balasubramanian, Patrick Sanvanson, Dilpesh Agrawal, Ashley Wuerl, Reza Shaker

Abstract read
In one paragraph

Article in American journal of physiology. Gastrointestinal and liver physiology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. Trial
  2. Article
  3. Article
  4. Article
  5. Article
  6. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Mark K KernDivision of Gastroenterology and Hepatology, Medical College of Wisconsin, Milwaukee, Wisconsin.
Gokulakrishnan BalasubramanianDivision of Gastroenterology and Hepatology, Medical College of Wisconsin, Milwaukee, Wisconsin.
Patrick SanvansonDivision of Gastroenterology and Hepatology, Medical College of Wisconsin, Milwaukee, Wisconsin.
Dilpesh AgrawalDivision of Gastroenterology and Hepatology, Medical College of Wisconsin, Milwaukee, Wisconsin.
Ashley WuerlDivision of Gastroenterology and Hepatology, Medical College of Wisconsin, Milwaukee, Wisconsin.
Reza ShakerDivision of Gastroenterology and Hepatology, Medical College of Wisconsin, Milwaukee, Wisconsin rshaker@mcw.edu.

Funding

Clinical and Translational Science AwardUL1TR001436 · NCATS · MEDICAL COLLEGE OF WISCONSIN · PI FREED, JULIE K · 2015 to 2025
$47.5M
The Physiology of the Pharyngo-Esophageal JunctionP01DK068051 · NIDDK · MEDICAL COLLEGE OF WISCONSIN · PI SHAKER, REZA NONE · 2007 to 2018
$11.6M
ESOPHAGEAL MOTOR FUNCTION IN HEALTH AND DISEASER01DK025731 · NIDDK · MEDICAL COLLEGE OF WISCONSIN · PI SHAKER, REZA NONE · 1986 to 2015
$5.7M
GASTROENTEROLOGY RESEARCH TRAINING GRANTT32DK061923 · NIDDK · MEDICAL COLLEGE OF WISCONSIN · PI SHAKER, REZA NONE · 2002 to 2019
$2.8M
NCATS NIH HHS UL1 TR001436NIDDK NIH HHS P01 DK068051NIDDK NIH HHS R01 DK025731NIDDK NIH HHS T32 DK061923
6 · The paper itself

Abstract

The present understanding of pharyngeal motor function remains incomplete. Among the remaining gaps of knowledge in this regard is the magnitude of variability of pharyngeal peristaltic pressure amplitude. Although variability can pose difficulty in interpretation of manometric findings, its magnitude can inform the operational range and reserve of the pharyngeal contractile function. We aimed to define the intra- and intersubject and intersession variability of select pharyngeal manometric parameters and, using this information, determine the number of swallow repetitions for acquiring reliable pharyngeal manometric data. We recorded pharyngeal peristalsis in 10 healthy subjects (age: 50 ± 25 yr, 5 women) by high-resolution manometry during two separate sessions of 20 sequences of 0.5-ml water swallows. Two-way ANOVA showed significant variation in the mean peak peristaltic pressure value across sites (

Indexed as

DeglutitionFemaleHumansMaleManometryMiddle AgedMuscle ContractionPeristalsisPharyngeal MusclesPharynxPressureReproducibility of ResultsSensitivity and Specificitydysphagiaestimated optimal sample size for pharyngeal pressure metricshigh-resolution pharyngeal manometryswallowing

Identifiers

PMID28254773
PMCPMC5451558

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.