ArticleBehavioural brain research2017
Eveningness among late adolescent males predicts neural reactivity to reward and alcohol dependence 2 years later.
Article in Behavioural brain research, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
39 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Great Expectations: A Critical Review of and Suggestions for the Study of Reward Processing as a Cause and Predictor of Depression.Biological psychiatry · 2021Pooled it
- Reward Sensitivity's Associations with Morningness-Eveningness and Other Circadian-Coupled Behavioral Phenomena: A Systematic Review and Meta-Analysis of Cross-Sectional and Prospective Relationships.Clinical psychology : a publication of the Division of Clinical Psychology of the American Psychological Association · 2026Article
- Changes in Rest-Activity Rhythms in Adolescents as They Age: Associations With Brain and Behavioral Changes in the ABCD Study.Journal of the American Academy of Child and Adolescent Psychiatry · 2025Article
- Circadian rhythmicity and reinforcement processing: a dataset of MRI, fMRI, and behavioral measurements.Scientific data · 2025Article
- A biopsychosocial approach to sleep health during puberty: Individual and contextual aspects and the role of gender differences. A narrative review.Cogent mental health · 2025Review
- Sex- and Substance-Specific Associations of Circadian-Related Genes with Addiction in the UK Biobank Cohort Implicate Neuroplasticity Pathways.Brain sciences · 2024Article
- Disrupted Circadian Rhythms and Substance Use Disorders: A Narrative Review.Clocks & sleep · 2024Review
- Changes in rest-activity rhythms in adolescents as they age: associations with brain changes and behavior in the ABCD study.medRxiv : the preprint server for health sciences · 2024Article
- The Role of Cannabis and The Endocannabinoid System in Sleep Regulation and Cognition: A Review of Human and Animal Studies.Behavioral sleep medicine · 2024Review
- Adolescent circadian rhythm disruption increases reward and risk-taking.Frontiers in neuroscience · 2024Article
- Sleep-Related Predictors of Risk for Alcohol Use and Related Problems in Adolescents and Young Adults.Alcohol research : current reviews · 2024Review
- Development of morning-eveningness in adolescence: implications for brain development and psychopathology.Journal of child psychology and psychiatry, and allied disciplines · 2023Article
- Associations between specific sleep and circadian characteristics and alcohol use disorder criteria and problems.Addictive behaviors · 2022Article
- Chronotype Profile, Stress, Depression Level, and Temporomandibular Symptoms in Students with Type D Personality.Journal of clinical medicine · 2022Article
- A Comprehensive Review of the Literature on Sleep Difficulties and Suicidality in Youth to Inform an Integrative Developmental Model and Future Directions.Current sleep medicine reports · 2022Article
- Sexual Differences in Internet Gaming Disorder (IGD): From Psychological Features to Neuroanatomical Networks.Journal of clinical medicine · 2022Review
- Preliminary Evidence That Circadian Alignment Predicts Neural Response to Monetary Reward in Late Adolescent Drinkers.Frontiers in neuroscience · 2022Article
- The Ventral Tegmental Area and Nucleus Accumbens as Circadian Oscillators: Implications for Drug Abuse and Substance Use Disorders.Frontiers in physiology · 2022Review
- Dopamine D1 and D2 receptors are distinctly associated with rest-activity rhythms and drug reward.The Journal of clinical investigation · 2021Article
- Delayed circadian rhythms and substance abuse: dopamine transmission's time has come.The Journal of clinical investigation · 2021Article
Corrections and comments
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Authors and funding
5 authors.
Funding
Abstract
Eveningness, a preference for later sleep-wake timing, is linked to altered reward function, which may explain a consistent association with substance abuse. Notably, the extant literature rests largely on cross-sectional data, yet both eveningness and reward function show developmental changes. We examined whether circadian preference during late adolescence predicted the neural response to reward 2 years later. A sample of 93 males reported circadian preference and completed a monetary reward fMRI paradigm at ages 20 and 22. Primary analyses examined longitudinal paths from circadian preference to medial prefrontal cortex (mPFC) and ventral striatal (VS) reward responses. We also explored whether reward responses mediated longitudinal associations between circadian preference and alcohol dependence, frequency of alcohol use, and/or frequency of cannabis use. Age 20 eveningness was positively associated with age 22 mPFC and VS responses to win, but not associated with age 22 reactivity to reward anticipation. Age 20 eveningness was indirectly related to age 22 alcohol dependence via age 22 mPFC response to win. Our findings provide novel evidence that altered reward-related brain function could underlie associations between eveningness and alcohol use problems. Eveningness may be an under-recognized but modifiable risk factor for reward-related problems such as mood and substance use disorders.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.