Evidence map›Paper›PMID 28254428›Full record

ReviewNeuroscience and biobehavioral reviews2017

The behavioural, cognitive, and neural corollaries of blunted cardiovascular and cortisol reactions to acute psychological stress.

Douglas Carroll, Annie T Ginty, Anna C Whittaker, William R Lovallo, Susanne R de Rooij

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Neuroscience and biobehavioral reviews, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 108 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
108citing papers in PubMed, 3 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

108 citing papers in PubMed, 3 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Trial
  5. Trial
  6. Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. Article
  14. Article
  15. Review
  16. Observational
  17. Review
  18. Association Between Phasic Vagal-Mediated Heart Rate Variability and Momentary Exhaustion in Daily Life.Stress and health : journal of the International Society for the Investigation of Stress · 2025
    Article
  19. Article
  20. Article

48 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Douglas CarrollSchool of Sport, Exercise and Rehabilitation Sciences, University of Birmingham, Birmingham B15 2TT, UK.
Annie T GintyDepartment of Psychology and Neuroscience, Baylor University, Waco, TX, 76798, USA.
Anna C WhittakerSchool of Sport, Exercise and Rehabilitation Sciences, University of Birmingham, Birmingham B15 2TT, UK. Electronic address: a.c.phillips@bham.ac.uk.
William R LovalloDepartment of Psychiatry and Behavioral Sciences, University of Oklahoma Health Sciences Center and VA Medical Center, Oklahoma City, OK 73104, USA.
Susanne R de RooijDepartment of Clinical Epidemiology and Biostatistics, Academic Medical Centre, University of Amsterdam, 1100 DD Amsterdam, The Netherlands.

Funding

Psychophysiological Precursors of AlcoholismR01AA012207 · NIAAA · UNIV OF ARKANSAS FOR MED SCIS · PI ACHESON, ASHLEY, KOCHUNOV, PETER V. · 2001 to 2025
$9.0M
Neuroimaging in the Oklahoma Family Health Patterns ProjectR01AA019691 · NIAAA · UNIVERSITY OF OKLAHOMA HLTH SCIENCES CTR · PI LOVALLO, WILLIAM R · 2011 to 2013
$555k
NIAAA NIH HHS R01 AA012207NIAAA NIH HHS R01 AA019691
6 · The paper itself

Abstract

Recent research shows that blunted cardiovascular and cortisol reactions to acute psychological stress are associated with adverse behavioural and health outcomes: depression, obesity, bulimia, and addictions. These outcomes may reflect suboptimal functioning of the brain's fronto-limbic systems that are needed to regulate motivated behaviour in the face of challenge. In support of this, brain imaging data demonstrate fronto-limbic hypoactivation during acute stress exposure. Those demonstrating blunted reactions also show impairments of motivation, including lower cognitive ability, more rapid cognitive decline, and poorer performance on motivation-dependent tests of lung function. Persons exhibiting blunted stress reactivity display well established temperament characteristics, including neuroticism and impulsivity, characteristic of various behavioural disorders. Notably, the outcomes related to blunted stress reactivity are similar to those that define Reward Deficiency Syndrome. Accordingly, some individuals may be characterised by a broad failure in cardiovascular and cortisol responding to both stress and reward, reflecting fronto-limbic dysregulation. Finally, we proffer a model of blunted stress reactivity, its antecedents and sequelae, and identify future research priorities.

Indexed as

Cardiovascular SystemCognitionStress, PsychologicalDepressionHumansHydrocortisoneHydrocortisoneBehaviourBlunted stress reactivityCardiovascular activityCognitive abilityCortisolHealthNeural hypoactivation

Identifiers

PMID28254428
PMCPMC6741350

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.