ReviewDevelopmental cognitive neuroscience2017
Early life adversity during the infant sensitive period for attachment: Programming of behavioral neurobiology of threat processing and social behavior.
Review in Developmental cognitive neuroscience, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 43 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
43 citing papers in PubMed.
- Heightened sensitivity to the caregiving environment during adolescence: implications for recovery following early-life adversity.Journal of child psychology and psychiatry, and allied disciplines · 2021Trial
- The oxytocin system mediates behavioral and neurobiological alterations associated with early adversity.Molecular psychiatry · 2026Article
- Adolescent social isolation creates a latent vulnerability in maternal care with intergenerational social consequences, rescued by experienced mothers.bioRxiv : the preprint server for biology · 2026Article
- Indicators of physical and emotional health in infants during hospitalization in paediatric cardiac intensive care units.Frontiers in cardiovascular medicine · 2026Article
- Social circuits under developmental threat: Bridging rodent and human neuroscience.Developmental review : DR · 2025Article
- Protocol for modeling earned-secure attachment in rodents using the repeated cross-fostering procedure with a significant alternative caregiver.STAR protocols · 2025Article
- A sensitive period for the development of episodic-like memory in mice.Current biology : CB · 2025Article
- Building a social brain: Cells, circuits and behavior across the lifespan.Neurobiology of stress · 2025Review
- Sex-Specific Outcomes in a Rat Model of Early-Life Stress Due to Adverse Caregiving.Neurotoxicity research · 2025Article
- Secure attachment to caregiver prevents adult depressive symptoms in a sex-dependent manner: A translational study.iScience · 2024Article
- Testing a Conceptual Model of Early Adversity, Neural Function, and Psychopathology: Protocol for a Retrospective Observational Cohort Study.JMIR research protocols · 2024Observational
- Early-life prefrontal cortex inhibition and early-life stress lead to long-lasting behavioral, transcriptional, and physiological impairments.Molecular psychiatry · 2024Article
- Early life adversity reduces affiliative behavior with a stressed cagemate and leads to sex-specific alterations in corticosterone responses in adult mice.Hormones and behavior · 2024Article
- Childhood trauma is linked to epigenetic age deceleration in young adults with previous youth residential care placements.European journal of psychotraumatology · 2024Article
- Attachment and emotional regulation: examining the role of prefrontal cortex functions, executive functions, and mindfulness in their relationship.Cognitive processing · 2023Article
- Examination of the role of adrenergic receptor stimulation in the sensitization of neuroinflammatory-based depressive-like behavior in isolated Guinea pig pups.Stress (Amsterdam, Netherlands) · 2023Article
- For neuroscience, social history matters.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2023Review
- Infant pain vs. pain with parental suppression: Immediate and enduring impact on brain, pain and affect.PloS one · 2023Article
- Impact of Fkbp5 × early life adversity × sex in humanised mice on multidimensional stress responses and circadian rhythmicity.Molecular psychiatry · 2022Article
- Experimental Induction of Emotional and Sexual Intimacy: Exploring the Validity of the German Fast Friends Procedure in Individuals with and without Childhood Maltreatment.Archives of sexual behavior · 2022Article
Corrections and comments
- Erratum issuedErratum.2020
Authors and funding
3 authors.
Funding
Abstract
Animals, including humans, require a highly coordinated and flexible system of social behavior and threat evaluation. However, trauma can disrupt this system, with the amygdala implicated as a mediator of these impairments in behavior. Recent evidence has further highlighted the context of infant trauma as a critical variable in determining its immediate and enduring consequences, with trauma experienced from an attachment figure, such as occurs in cases of caregiver-child maltreatment, as particularly detrimental. This review focuses on the unique role of caregiver presence during early-life trauma in programming deficits in social behavior and threat processing. Using data primarily from rodent models, we describe the interaction between trauma and attachment during a sensitive period in early life, which highlights the role of the caregiver's presence in engagement of attachment brain circuitry and suppressing threat processing by the amygdala. These data suggest that trauma experienced directly from an abusive caregiver and trauma experienced in the presence of caregiver cues produce similar neurobehavioral deficits, which are unique from those resulting from trauma alone. We go on to integrate this information into social experience throughout the lifespan, including consequences for complex scenarios, such as dominance hierarchy formation and maintenance.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.