Evidence map›Paper›PMID 28254179›Full record

ArticleJournal of the American College of Cardiology2017

Neutrophil Counts and Initial Presentation of 12 Cardiovascular Diseases: A CALIBER Cohort Study.

Anoop Dinesh Shah, Spiros Denaxas, Owen Nicholas, Aroon D Hingorani, Harry Hemingway

Erratum issued Registry-linked trialOpen access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of the American College of Cardiology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. It is linked to trial NCT02014610 (Leukocyte Counts and Initial Presentation of Cardiovascular Diseases), which is not on this map. Cited by 108 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
108citing papers in PubMed, 2 pooled it
4.1field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02014610 unknown statusnot on this map

Leukocyte Counts and Initial Presentation of Cardiovascular Diseases: a CALIBER Study

TypeobservationalSponsorUniversity College, LondonRan1997 to 2014Enrolled800,000ConditionsAbdominal Aortic Aneurysm, Coronary Artery Disease, Stroke, Heart Failure
3 · Its place in the literature

Who cites it

108 citing papers in PubMed, 2 syntheses or guidelines pooled it, 154 citations in OpenAlex.

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48 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Anoop Dinesh ShahFarr Institute of Health Informatics Research, UCL Institute of Health Informatics, University College London, London, United Kingdom; University College London Hospitals NHS Foundation Trust, London, United Kingdom. Electronic address: anoop@doctors.org.uk.
Spiros DenaxasFarr Institute of Health Informatics Research, UCL Institute of Health Informatics, University College London, London, United Kingdom.
Owen NicholasNational Institute for Cardiovascular Outcomes Research, UCL Institute of Cardiovascular Science, University College London, London, United Kingdom.
Aroon D HingoraniFarr Institute of Health Informatics Research, UCL Institute of Health Informatics, University College London, London, United Kingdom; University College London Hospitals NHS Foundation Trust, London, United Kingdom.
Harry HemingwayFarr Institute of Health Informatics Research, UCL Institute of Health Informatics, University College London, London, United Kingdom.
University College London · GBUniversity College London Hospitals NHS Foundation Trust · GB

Funding

Department of Health RP-PG-0407-10314Medical Research Council MR/K006584/1Wellcome Trust
6 · The paper itself

Abstract

backgroundNeutrophil counts are a ubiquitous measure of inflammation, but previous studies on their association with cardiovascular disease (CVD) were limited by small numbers of patients or a narrow range of endpoints.

objectivesThis study investigated associations of clinically recorded neutrophil counts with initial presentation for a range of CVDs.

methodsWe used linked primary care, hospitalization, disease registry, and mortality data in England. We included people 30 years or older with complete blood counts performed in usual clinical care and no history of CVD. We used Cox models to estimate cause-specific hazard ratios (HRs) for 12 CVDs, adjusted for cardiovascular risk factors and acute conditions affecting neutrophil counts (such as infections and cancer).

resultsAmong 775,231 individuals in the cohort, 154,179 had complete blood counts performed under acute conditions and 621,052 when they were stable. Over a median 3.8 years of follow-up, 55,004 individuals developed CVD. Adjusted HRs comparing neutrophil counts 6 to 7 versus 2 to 3 × 10

conclusionsNeutrophil counts were strongly associated with the incidence of some CVDs, but not others, even within the normal range, consistent with underlying disease mechanisms differing across CVDs. (White Blood Cell Counts and Onset of Cardiovascular Diseases: a CALIBER Study [CALIBER]; NCT02014610).

Indexed as

Leukocyte CountNeutrophilsAdultAgedCardiovascular DiseasesCohort StudiesEnglandFemaleHumansIncidenceMaleMiddle AgedProportional Hazards Modelsdisease mechanismselectronic health recordsepidemiologyincidenceinflammation

Identifiers

PMID28254179
PMCPMC5332591
OpenAlexW2594314982

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.