Evidence map›Paper›PMID 28254124›Full record

Observational studyJACC. Heart failure2017

Left Ventricular Function Across the Spectrum of Body Mass Index in African Americans: The Jackson Heart Study.

Vivek G Patel, Deepak K Gupta, James G Terry, Edmond K Kabagambe, Thomas J Wang, Aldolfo Correa, Michael Griswold, Herman Taylor, John Jeffrey Carr

Abstract readObservational Study
PubMed Full text at PMC Publisher
In one paragraph

Observational study in JACC. Heart failure, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed, 1 pooled it
0.9field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 1 synthesis or guideline pooled it, 14 citations in OpenAlex.

  1. Pooled it
  2. Article
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  7. Article
  8. Article
  9. Leptin Levels are Associated with Subclinical Cardiac Dysfunction in Obese Adolescents.Diabetes, metabolic syndrome and obesity : targets and therapy · 2020
    Article
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  11. Observational
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Vivek G PatelVanderbilt University School of Medicine, Nashville, Tennessee; Vanderbilt Translational and Clinical Cardiovascular Research Center, Nashville, Tennessee. Electronic address: vivek.patel@vanderbilt.edu.
Deepak K GuptaVanderbilt University School of Medicine, Nashville, Tennessee; Vanderbilt Translational and Clinical Cardiovascular Research Center, Nashville, Tennessee.
James G TerryVanderbilt University School of Medicine, Nashville, Tennessee; Vanderbilt Translational and Clinical Cardiovascular Research Center, Nashville, Tennessee.
Edmond K KabagambeVanderbilt University School of Medicine, Nashville, Tennessee; Vanderbilt Translational and Clinical Cardiovascular Research Center, Nashville, Tennessee; Jackson Heart Study Vanguard Center at Vanderbilt University, Nashville, Tennessee.
Thomas J WangVanderbilt University School of Medicine, Nashville, Tennessee; Vanderbilt Translational and Clinical Cardiovascular Research Center, Nashville, Tennessee.
Aldolfo CorreaUniversity of Mississippi Medical Center, Jackson, Mississippi.
Michael GriswoldUniversity of Mississippi Medical Center, Jackson, Mississippi.
Herman TaylorUniversity of Mississippi Medical Center, Jackson, Mississippi; Morehouse School of Medicine, Atlanta, Georgia.
John Jeffrey CarrVanderbilt University School of Medicine, Nashville, Tennessee; Vanderbilt Translational and Clinical Cardiovascular Research Center, Nashville, Tennessee.
Vanderbilt University · USUniversity of Mississippi Medical Center · US

Funding

The Vanderbilt Emergency Medicine Research Training Program (VEMRT)K12HL109019 · NHLBI · VANDERBILT UNIVERSITY MEDICAL CENTER · PI COLLINS, SEAN PATRICK, STORROW, ALAN B · 2011 to 2015
$3.7M
Obesity, salt-sensitivity, and the natriuretic peptidesR01HL102780 · NHLBI · VANDERBILT UNIVERSITY · PI WANG, THOMAS J. · 2011 to 2014
$1.7M
The natriuretic peptide system in African-AmericansK23HL128928 · NHLBI · VANDERBILT UNIVERSITY MEDICAL CENTER · PI GUPTA, DEEPAK · 2016 to 2019
$737k
NHLBI NIH HHS HHSN268201300046CNHLBI NIH HHS HHSN268201300047CNHLBI NIH HHS HHSN268201300048CNHLBI NIH HHS HHSN268201300049CNHLBI NIH HHS HHSN268201300050CNHLBI NIH HHS K12 HL109019NHLBI NIH HHS K23 HL128928NHLBI NIH HHS R01 HL102780
6 · The paper itself

Abstract

objectivesThis study sought to assess whether body mass index (BMI) was associated with subclinical left ventricular (LV) systolic dysfunction in African-American individuals.

backgroundHigher BMI is a risk factor for cardiovascular disease, including heart failure. Obesity disproportionately affects African Americans; however, the association between higher BMI and LV function in African Americans is not well understood.

methodsPeak systolic circumferential strain (ECC) was measured by tagged cardiac magnetic resonance in 1,652 adult African-American participants of the Jackson Heart Study between 2008 and 2012. We evaluated the association between BMI and ECC in multivariate linear regression and restricted cubic spline analyses adjusted for prevalent cardiovascular disease, conventional cardiovascular risk factors, LV mass, and ejection fraction. In exploratory analyses, we also examined whether inflammation, insulin resistance, or volume of visceral adipose tissue altered the association between BMI and ECC.

resultsThe proportions of female, nonsmokers, diabetic, and hypertensive participants rose with increase in BMI. In multivariate-adjusted models, higher BMI was associated with worse ECC (β = 0.052; 95% confidence interval: 0.028 to 0.075), even in the setting of preserved LV ejection fraction. Higher BMI was also associated with worse ECC when accounting for markers of inflammation (C-reactive protein, E-selection, and P-selectin), insulin resistance, and volume of visceral adipose tissue.

conclusionsHigher BMI is significantly associated with subclinical LV dysfunction in African Americans, even in the setting of preserved LV ejection fraction.

Indexed as

Black or African AmericanAgedBody Mass IndexCohort StudiesC-Reactive ProteinE-SelectinFemaleHumansInflammationInsulin ResistanceIntra-Abdominal FatLinear ModelsMagnetic Resonance ImagingMagnetic Resonance Imaging, CineMaleMiddle AgedC-Reactive ProteinE-SelectinP-SelectinSELE protein, humanSELP protein, humanBMIcardiovascular diseaseheart failureJackson Heart StudyLV function

Identifiers

PMID28254124
PMCPMC5338642
OpenAlexW2591650225

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.