ArticleVirchows Archiv. A, Pathological anatomy and histopathology1987
Mediastinal large-cell lymphoma with sclerosis. Genotypic analysis establishes its B nature.
Article in Virchows Archiv. A, Pathological anatomy and histopathology, 1987. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed.
- Primary mediastinal large B-cell lymphoma (PMLBCL): long-term results from a retrospective multicentre Italian experience in 138 patients treated with CHOP or MACOP-B/VACOP-B.British journal of cancer · 2004Trial
- [Mediastinal large B-cell lymphoma].Der Pathologe · 2007Article
- Primary mediastinal B-cell lymphoma: high frequency of BCL-6 mutations and consistent expression of the transcription factors OCT-2, BOB.1, and PU.1 in the absence of immunoglobulins.The American journal of pathology · 2003Article
- Discordant expression of immunoglobulin and its associated molecule mb-1/CD79a is frequently found in mediastinal large B cell lymphomas.The American journal of pathology · 1995Article
- Mediastinal large-cell lymphoma with sclerosis (MLCLS).British journal of cancer · 1994Article
- Adhesion receptor profile of thymic B-cell lymphoma.The American journal of pathology · 1992Article
- Tumours of the thymus and their nomenclature.Virchows Archiv. A, Pathological anatomy and histopathology · 1991Review
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9 authors.
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Abstract
The Southern blot hybridization technique has been applied to study the configuration of immunoglobulin and T-cell receptor genes in 6 cases of the so called mediastinal large cell lymphoma with sclerosis. This lymphoma has been recently recognized as a separate entity among non-Hodgkin lymphomas mainly affecting young adult patients. The B-cell origin of this neoplasm was suggested by means of immunohistochemical analysis. However, the immunophenotypical B-cell related markers used do not always exhibit lineage fidelity. The Southern blot analysis demonstrated the presence of unique heavy and k-light chain immunoglobulin gene rearrangements, establishing genotypically their B-cell origin.
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