ReviewMalaria journal2017
Evidence of metabolic mechanisms playing a role in multiple insecticides resistance in Anopheles stephensi populations from Afghanistan.
Review in Malaria journal, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 1 of them a synthesis that pooled it.
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Who cites it
23 citing papers in PubMed, 1 synthesis or guideline pooled it, 49 citations in OpenAlex.
- Evolution of insecticide resistance and its mechanisms in Anopheles stephensi in the WHO Eastern Mediterranean Region.Malaria journal · 2020Pooled it
- Historical Overview of the Bionomics ofJournal of arthropod-borne diseases · 2026Review
- Environmental persistence and transmission dynamics ofApplied and environmental microbiology · 2025Article
- Genome wide population genetics and molecular surveillance of insecticide resistance in Anopheles stephensi mosquitoes from Awash Sebat Kilo in Ethiopia.Scientific reports · 2025Article
- The origin, invasion history and resistance architecture ofbioRxiv : the preprint server for biology · 2025Article
- Possible potential spread of Anopheles stephensi, the Asian malaria vector.BMC infectious diseases · 2024Article
- Ace-1 Target Site Status and Metabolic Detoxification Associated with Bendiocarb Resistance in the Field Populations of Main Malaria Vector,Journal of arthropod-borne diseases · 2023Article
- Persistent susceptibility of Aedes aegypti to eugenol.Scientific reports · 2022Article
- Contribution of insect gut microbiota and their associated enzymes in insect physiology and biodegradation of pesticides.Frontiers in microbiology · 2022Review
- Metabolic detoxification andFrontiers in physiology · 2022Article
- Gradual reduction of susceptibility and enhanced detoxifying enzyme activities of laboratory-rearedToxicology reports · 2021Article
- Biochemical Mechanism of Insecticide Resistance in Malaria Vector,Iranian journal of public health · 2021Article
- Insecticide resistance in Anopheles stephensi in Somali Region, eastern Ethiopia.Malaria journal · 2020Article
- Symbiotic Fungus Affected the Asian Citrus Psyllid (ACP) Resistance to Imidacloprid and Thiamethoxam.Frontiers in microbiology · 2020Article
- First Report of Biochemical Mechanisms of Insecticide Resistance in the Field Population ofJournal of arthropod-borne diseases · 2019Article
- Status of insecticide resistance and its biochemical and molecular mechanisms in Anopheles stephensi (Diptera: Culicidae) from Afghanistan.Malaria journal · 2019Article
- Insecticide Resistance Status and Mechanisms of Anopheles sinensis (Diptera: Culicidae) in Wenzhou, an Important Coastal Port City in China.Journal of medical entomology · 2019Article
- Evaluation of resistance to temephos insecticide inAfrican health sciences · 2019Article
- Plant-Derived Essential Oils; Their Larvicidal Properties and Potential Application for Control of Mosquito-Borne Diseases.Galen medical journal · 2019Review
- Characterization and monitoring of deltamethrin-resistance in Anopheles culicifacies in the presence of a long-lasting insecticide-treated net intervention.Malaria journal · 2018Article
Corrections and comments
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Authors and funding
8 authors at 4 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundMalaria is endemic in most parts of Afghanistan and insecticide-based vector control measures are central in controlling the disease. Insecticide resistance in the main malaria vector Anopheles stephensi from Afghanistan is increasing and attempts should be made to determine the underlying resistance mechanisms for its adequate management.
methodsThe contents of cytochrome P450s, esterases, glutathione S-transferases (GSTs) and acetylcholine esterase (AChE) activities were measured in the Kunar and Nangarhar populations of An. stephensi from Afghanistan and the results were compared with those of the susceptible Beech strain using the World Health Organization approved biochemical assay methods for adult mosquitoes.
resultsThe cytochrome P450s enzyme ratios were 2.23- and 2.54-fold in the Kunar and Nangarhar populations compared with the susceptible Beech strain. The enzyme ratios for esterases with alpha-naphthyl acetate were 1.45 and 2.11 and with beta-naphthyl acetate were 1.62 and 1.85 in the Kunar and Nangarhar populations respectively compared with the susceptible Beech strain. Esterase ratios with para-nitrophenyl acetate (pNPA) were 1.61 and 1.75 in the Kunar and Nangarhar populations compared with the susceptible Beech strain. The GSTs enzyme ratios were 1.33 and 1.8 in the Kunar and Nangarhar populations compared with the susceptible Beech strain. The inhibition of AChE was 70.9 in the susceptible Beech strain, and 56.7 and 51.5 in the Kunar and Nangarhar populations. The differences between all values of the enzymes activities/contents and AChE inhibition rates in the Kunar and Nangarhar populations were statistically significant when compared with those of the susceptible Beech strain.
conclusionsBased on the results, the reported resistance to pyrethroid and organophosphate insecticides, and tolerance to bendiocarb in the Kunar and Nangarhar populations of An. stephensi from Afghanistan are likely to be caused by a range of metabolic mechanisms, including esterases, P450s and GSTs combined with target site insensitivity in AChE.
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