Evidence map›Paper›PMID 28253432›Full record

ArticleChembiochem : a European journal of chemical biology2017

Spectroscopic and Computational Investigations of Ligand Binding to IspH: Discovery of Non-diphosphate Inhibitors.

Bing O'Dowd, Sarah Williams, Hongxin Wang, Joo Hwan No, Guodong Rao, Weixue Wang, J Andrew McCammon, Stephen P Cramer, Eric Oldfield

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Chembiochem : a European journal of chemical biology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. Article
  2. Article
  3. Resonance Raman Spectroscopic Study of the Unusual [4Fe-4S]Chembiochem : a European journal of chemical biology · 2025
    Article
  4. Review
  5. Review
  6. Microbial (Frontiers in bioengineering and biotechnology · 2022
    Review
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Bing O'DowdDepartment of Chemistry, University of Illinois, 600 South Mathews Avenue, Urbana, IL, 61801, USA.
Sarah WilliamsDepartment of Chemistry and Biochemistry, University of California at San Diego, La Jolla, CA, 92093, USA.
Hongxin WangDepartment of Chemistry, University of California, 1 Shields Avenue, Davis, CA, 95616, USA.
Joo Hwan NoCenter for Biophysics and Computational Biology, 607 South Mathews Avenue, Urbana, IL, 61801, USA.
Guodong RaoDepartment of Chemistry, University of Illinois, 600 South Mathews Avenue, Urbana, IL, 61801, USA.
Weixue WangCenter for Biophysics and Computational Biology, 607 South Mathews Avenue, Urbana, IL, 61801, USA.
J Andrew McCammonDepartment of Chemistry and Biochemistry, University of California at San Diego, La Jolla, CA, 92093, USA.
Stephen P CramerDepartment of Chemistry, University of California, 1 Shields Avenue, Davis, CA, 95616, USA.
Eric OldfieldDepartment of Chemistry, University of Illinois, 600 South Mathews Avenue, Urbana, IL, 61801, USA.

Funding

National Biomedical Computation Resource - Competitive Revision SupplementP41GM103426 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI AMARO, ROMMIE E · 2012 to 2019
$14.0M
THEORY OF BIOMOLECULAR DIFFUSIONR01GM031749 · NIGMS · UNIVERSITY OF HOUSTON · PI HUBER, GARY ALEXANDER, MCCAMMON, JAMES ANDREW · 1985 to 2022
$7.8M
X-Ray Raman and Vibrational Mossbauer of MetalloproteinsR01GM065440 · NIGMS · UNIVERSITY OF CALIFORNIA DAVIS · PI CRAMER, STEPHEN P. · 2002 to 2025
$7.3M
Structure, Function and Inhibition of [4Fe-4S] ProteinsR01GM065307 · NIGMS · UNIVERSITY OF ILLINOIS URBANA-CHAMPAIGN · PI OLDFIELD, ERIC · 2002 to 2017
$5.4M
Multifrequency Pulsed Electron Paramagnetic Resonance Spectrometer For BiomedicalS10RR025438 · NCRR · UNIVERSITY OF ILLINOIS AT URBANA-CHAMPAIGN · PI DIKANOV, SERGEI A · 2009 to 2009
$397k
NCRR NIH HHS S10 RR025438NIGMS NIH HHS P41 GM103426NIGMS NIH HHS R01 GM031749NIGMS NIH HHS R01 GM065307NIGMS NIH HHS R01 GM065440
6 · The paper itself

Abstract

Isoprenoid biosynthesis is an important area for anti-infective drug development. One isoprenoid target is (E)-1-hydroxy-2-methyl-but-2-enyl 4-diphosphate (HMBPP) reductase (IspH), which forms isopentenyl diphosphate and dimethylallyl diphosphate from HMBPP in a 2H

Indexed as

Computational BiologyElectron Spin Resonance SpectroscopyEnzyme InhibitorsHemiterpenesHumansIronIron-Sulfur ProteinsModels, MolecularMolecular StructureOrganophosphatesOrganophosphorus CompoundsProtein ConformationSulfur4-hydroxy-3-methyl-2-butenyl diphosphateEnzyme InhibitorsHemiterpenesIronIron-Sulfur Proteinsisopentenyl pyrophosphateOrganophosphatesOrganophosphorus CompoundsSulfurHYSCOREin silicoisoprenoidIspHNRVS

Identifiers

PMID28253432
PMCPMC5445010

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.