ArticleJournal of hypertension2017
Objective short sleep duration modifies the relationship between hypertension and all-cause mortality.
Article in Journal of hypertension, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 33 citations in OpenAlex.
- Associations of work-related stress and total sleep time with cholesterol levels in an occupational cohort of Japanese office workers.Journal of occupational health · 2021Trial
- Social disadvantage, insufficient sleep, and cardiovascular disease.Frontiers in sleep · 2025Review
- Edward O. Bixler, PhD: from the Apollo project and chimpanzees to sleep epidemiology.Sleep advances : a journal of the Sleep Research Society · 2024Article
- Investigating the causal interplay between sleep traits and risk of acute myocardial infarction: a Mendelian randomization study.BMC medicine · 2023Article
- The effect and relative importance of sleep disorders for all-cause mortality in middle-aged and older asthmatics.BMC geriatrics · 2022Article
- Sleep and Exercise among Young Doctors in a Tertiary Care Hospital in India: A Pilot Cross-Sectional Study.Journal of lifestyle medicine · 2022Article
- Association between nocturnal sleep duration and the risk of hyperuricemia among Chinese government employees: A cross-sectional study.Frontiers in public health · 2022Article
- Associations Between Incident Asthma With Comorbidity Profiles, Night Sleep Duration, and Napping Duration Trajectories: A 7-Year Prospective Study.International journal of public health · 2022Article
- Association of long-term sleep habits and hypertension: a cross-sectional study in Chinese adults.Journal of human hypertension · 2020Article
- Short Sleep, Insomnia, and Cardiovascular Disease.Current sleep medicine reports · 2019Article
- Delayed Sleep Time in African Americans and Depression in a Community-Based Population.Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine · 2019Article
- Long Sleep Duration, Insomnia, and Insomnia With Short Objective Sleep Duration Are Independently Associated With Short Telomere Length.Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine · 2018Article
- Objectively Measured Disrupted Sleep Is Independently and Directly Associated With Low Exercise Capacity in Males: A Structural Equation Model.Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine · 2018Article
Corrections and comments
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Authors and funding
5 authors at 4 institutions in 4 countries.
Funding
Abstract
objectiveShort sleep duration has been associated with cardiovascular morbidity and mortality. However, previous studies were limited by using subjective sleep measures and treating sleep duration as a sole, independent predictor. Therefore, the role of sleep duration in predicting mortality is still not well understood. We posit that objective sleep duration is an effect modifier of the relationship between hypertension and all-cause mortality.
methodsWe addressed this question in the Penn State Adult Cohort, a random, general population sample of 1741 men and women (48.7 ± 13.5 years) who were studied in the sleep laboratory and followed up for 15.5 ± 4.1 years. Hypertension was defined on the basis of SBP and DBP (≥140/≥90 mmHg) or use of antihypertensive medication. Polysomnographic sleep duration was classified into three clinically meaningful categories.
resultsWe tested the interaction between hypertension and polysomnographic sleep duration on all-cause mortality using multiple logistic regression while controlling for several potential confounders (P value = 0.03). The odds (95% confidence interval) of all-cause mortality associated with hypertension were 1.77 (1.07-2.92), 2.78 (1.47-5.24), and 3.93 (2.22-6.95) for individuals who slept at least 6, 5-6, and 5 h or less, respectively.
conclusionThe risk of mortality associated with hypertension increases in a dose-response manner as a function of shorter sleep duration. Short sleep in hypertensive individuals may be a marker of the degree of central autonomic dysfunction. Future epidemiological studies should examine this effect modification using cause-specific mortality, whereas future clinical trials should examine whether lengthening sleep improves the prognosis of individuals with hypertension.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.