SynthesisJournal of hypertension2017
White-coat hypertension is a risk factor for cardiovascular diseases and total mortality.
Synthesis in Journal of hypertension, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 85 papers, 11 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
85 citing papers in PubMed, 11 syntheses or guidelines pooled it, 201 citations in OpenAlex.
- Brazilian Guidelines for In-office and Out-of-office Blood Pressure Measurement - 2023.Arquivos brasileiros de cardiologia · 2024Guideline
- Pooled it
- Prognostic Impact of Metabolic Syndrome in Patients With Heart Failure: A Meta-Analysis of Observational Studies.Frontiers in cardiovascular medicine · 2021Pooled it
- Association Between Hemoglobin Glycation Index and Risk of Cardiovascular Disease and All Cause Mortality in Type 2 Diabetic Patients: A Meta-Analysis.Frontiers in cardiovascular medicine · 2021Pooled it
- Diagnostic performance of clinic and home blood pressure measurements compared with ambulatory blood pressure: a systematic review and meta-analysis.BMC cardiovascular disorders · 2020Pooled it
- Association between prediabetes and risk of all cause mortality and cardiovascular disease: updated meta-analysis.BMJ (Clinical research ed.) · 2020Pooled it
- Prognosis of unrecognised myocardial infarction determined by electrocardiography or cardiac magnetic resonance imaging: systematic review and meta-analysis.BMJ (Clinical research ed.) · 2020Pooled it
- Masked and white coat hypertension, the double trouble of large arteries: A systematic review and meta-analysis.Journal of clinical hypertension (Greenwich, Conn.) · 2020Pooled it
- Cardiovascular Events and Mortality in White Coat Hypertension: A Systematic Review and Meta-analysis.Annals of internal medicine · 2019Pooled it
- Are the cardiovascular outcomes of participants with white-coat hypertension poor compared to those of participants with normotension? A systemic review and meta-analysis.Hypertension research : official journal of the Japanese Society of Hypertension · 2019Pooled it
- Pooled it
- Antihypertensive drug treatment in white-coat hypertension: data from the Plaque HYpertension Lipid-Lowering Italian Study.Journal of hypertension · 2022Trial
- Cardiovascular frailty - an emerging frailty phenotype.Journal of human hypertension · 2026Review
- Interaction between white coat effect and hypertension on arterial stiffness.Journal of hypertension · 2026Article
- Distinct associations of blood pressure phenotypes with subclinical cerebrovascular disease and coronary artery calcification in Japanese men.Hypertension research : official journal of the Japanese Society of Hypertension · 2026Observational
- Electrophysiological Response in Hypertensive Crisis: An Evaluation of the ICEB Score.Medicina (Kaunas, Lithuania) · 2026Article
- Brazilian Guidelines of Hypertension - 2025.Arquivos brasileiros de cardiologia · 2025Article
- Prognostic Impact of Different Definitions of White-Coat Hypertension.American journal of hypertension · 2025Article
- Placental epigenetic age and adolescent blood pressure: the Extremely Low Gestational Age Newborn cohort.Pediatric research · 2025Article
- Interplay of gut microbiome and metabolome in various blood pressure phenotypes based on ambulatory BP monitoring reveal new insights in nondipper patients.Journal of hypertension · 2025Article
25 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
10 authors at 1 institution in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundWhether white-coat hypertension (WCH) is an innocent phenomenon is controversial.
methodIn this study, we evaluated the association of WCH and the risk of cardiovascular diseases (CVDs) and mortality, stratified by baseline antihypertensive treatment status. Databases (PubMed, EMBASE, CINAHL Plus, Scopus, and Google Scholar) were searched for prospective studies with data on CVD and total mortality associated with WCH. The primary outcomes were the risk of CVD and total mortality associated with WCH stratified by antihypertensive treatment status. The relative risks of events compared with normotension were calculated.
resultsA total of 23 cohorts (20 445 individuals), 11 cohorts (8656 individuals), and 12 cohorts (21 336 individuals) were included for analysis of cardiovascular risk associated with WCH in patients without baseline antihypertensive treatment (untreated), or under antihypertensive treatment (treated) or mixed population (including both untreated and treated patients), respectively. In untreated cohorts, WCH was associated with a 38 and 20% increased risk of CVD and total mortality compared with normotension, respectively. In the mixed population, WCH was associated with a 19 and 50% increased risk of CVD and total mortality. However, in the treated patients, neither the risk of CVD, nor total mortality was increased in WCH. Meta-regression analyses indicated that neither differences of clinic blood pressure, nor out-of-office blood pressure variables were correlated with risk of CVD in WCH.
conclusionWe concluded that WCH is associated with long-term risk of CVD and total mortality in patients without antihypertensive treatment. Close follow-up should be performed in WCH patients.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.